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Reference.org
Neovascularization
open-in-new
<p>Neovascularization is the natural formation of new <a href="/facts/Blood_vessel/FG3GjPNW">blood vessels</a> (<i>neo-</i> + <i>vascular</i> + <i>-ization</i>), usually in the form of functional <a href="/facts/Microvessel/EecoBYyz">microvascular</a> networks, capable of <a href="/facts/Perfusion/EFVLNUTg">perfusion</a> by <a href="/facts/Red_blood_cell/Kggpq8Jh">red blood cells</a>, that form to serve as <a href="/facts/Collateral_circulation/z3E3Kn82">collateral circulation</a> in response to local poor perfusion or <a href="/facts/Ischemia/ySL9xbCl">ischemia</a>. </p><p>Growth factors that inhibit neovascularization include those that affect endothelial cell division and differentiation. These growth factors often act in a <a href="/facts/Paracrine_signalling/V8eVwG9z">paracrine</a> or <a href="/facts/Autocrine_signalling/EwfQEYzG">autocrine</a> fashion; they include <a href="/facts/Fibroblast_growth_factor/eC48LP3g">fibroblast growth factor</a>, <a href="/facts/Placental_growth_factor/XBss1E4W">placental growth factor</a>, <a href="/facts/Insulin-like_growth_factor/gYqfrKPy">insulin-like growth factor</a>, <a href="/facts/Hepatocyte_growth_factor/7WLEIPn4">hepatocyte growth factor</a>, and <a href="/facts/Platelet-derived_endothelial_growth_factor/uQAwpFHw">platelet-derived endothelial growth factor</a>. </p><p>There are three different pathways that comprise neovascularization: (1) <a href="/facts/Vasculogenesis/CCStKYHz">vasculogenesis</a>, (2) <a href="/facts/Angiogenesis/h0HF9IUd">angiogenesis</a>, and (3) <a href="/facts/Arteriogenesis/lJGKralJ">arteriogenesis</a>. </p>