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Nucleoside-modified messenger RNA
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<p>A nucleoside-modified messenger RNA (modRNA) is a synthetic <a href="/facts/Messenger_RNA/oUL6qxQn">messenger RNA</a> (mRNA) in which some <a href="/facts/Nucleoside/G40crf0F">nucleosides</a> are replaced by other naturally modified nucleosides or by synthetic <a href="/facts/Nucleoside_analogue/DEr9cQYD">nucleoside analogues</a>. modRNA is used to induce the <a href="/facts/Protein_biosynthesis/P4IcGjPd">production of a desired protein</a> in certain cells. An important application is the development of <a href="/facts/RNA_vaccine/PCUBVuSw">mRNA vaccines</a>, of which the first authorized were <a href="/facts/COVID-19_vaccine/obToxWTT">COVID-19 vaccines</a> (such as <a href="/facts/Pfizer%E2%80%93BioNTech_COVID-19_vaccine/T0AYCJ9p">Comirnaty</a> and <a href="/facts/Moderna_COVID-19_vaccine/2rlX6oWc">Spikevax</a>). </p>