Machine perfusion

<p>Machine perfusion (MP) is an artificial <a href="/facts/Perfusion/EFVLNUTg">perfusion</a> technique often used for organ preservation to help facilitate <a href="/facts/Organ_transplantation/1jNvVJn6">organ transplantation</a>. MP works by continuously pumping a specialized solution through <a href="/facts/Organ_donation/wgHzQ3c4">donor organs</a>, mimicking the body's natural <a href="/facts/Hemodynamics/HzubzJpn">blood flow</a> while actively controlling <a href="/facts/Thermoregulation/V692hIjw">temperature</a>, <a href="/facts/Oxygen_saturation/UVhwuc26">oxygen levels</a>, <a href="/facts/Composition_of_the_human_body/bbPXIH0x">chemical composition</a>, and mechanical stress within the organ. By maintaining organ viability outside the body for extended periods, machine perfusion addresses critical challenges in organ transplantation, such as limited preservation times.
</p><p>Machine perfusion has various forms and can be categorised according to the temperature of the perfusate: cold (4 °C) and warm (37 °C). Machine perfusion has been applied to <a href="/facts/Kidney_transplantation/WMeCmTBL">renal transplantation</a>, <a href="/facts/Liver_transplantation/0noMXT50">liver transplantation</a> and <a href="/facts/Lung_transplantation/Yc2BIroT">lung transplantation</a>. It is an alternative to static <a href="/facts/Refrigeration/Bs8HHbYd">cold storage</a> (SCS).
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Machine perfusion open-in-new

Machine perfusion