NOVA1

RNA-binding protein Nova-1 is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the NOVA1 <a href="/facts/Gene/e1swwPY6">gene</a>.
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of <a href="/facts/Paraneoplastic_disease/Dvqdu7QX">paraneoplastic disease</a> antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. <a href="/facts/Alternative_splicing/nNRwPVNK">Alternatively spliced</a> transcripts encoding distinct <a href="/facts/Isoform/oWmzfg4l">isoforms</a> have been described. Both Neanderthals and Denisovans had one version and nearly all modern humans had another suggesting positive selection. Insertion of Neanderthal gene variant of the neuro-oncological ventral antigen 1 (NOVA1) gene into human cortical organoids might promote slower development and higher surface complexity in the brain models, but this may be an artefact of a <a href="/facts/CRISPR/VqRDofqC">CRISPR</a> side effect, as it could not be <a href="/facts/Replication_(scientific_method)/yh5pawMj">replicated</a> in a subsequent study.

NOVA1 open-in-new

NOVA1