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Formate C-acetyltransferase
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<p>In <a href="/facts/Enzymology/DSI1Fh7y">enzymology</a>, formate C-acetyltransferase (<i>pyruvate formate lyase</i>) (<a href="/facts/Enzyme_Commission_number/Y5GNLRKX">EC</a> <a href="https://enzyme.expasy.org/EC/2.3.1.54">2.3.1.54</a>) is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a>. Pyruvate formate lyase is found in <i><a href="/facts/Escherichia_coli/nR4Gvl56">Escherichia coli</a></i> and other <a href="/facts/Organism/j8JkL09u">organisms</a>. It helps regulate <a href="/facts/Anaerobic_respiration/IMSY03HG">anaerobic</a> <a href="/facts/Glucose/oUSkoLCD">glucose</a> <a href="/facts/Metabolism/WxDrm8k5">metabolism</a>. Using radical non-redox chemistry, it <a href="/facts/Catalysis/LPBS7TQC">catalyzes</a> the reversible conversion of <a href="/facts/Pyruvate/qJTgl4J9">pyruvate</a> and <a href="/facts/Coenzyme-A/loAfeGpx">coenzyme-A</a> into <a href="/facts/Formate/Py3GhI7L">formate</a> and <a href="/facts/Acetyl-CoA/XyxFfC84">acetyl-CoA</a>. The reaction occurs as follows: </p><p>This enzyme belongs to the family of <a href="/facts/Transferase/ut43BDxU">transferases</a>, specifically those <a href="/facts/Acyltransferase/vwfM9UCv">acyltransferases</a> transferring groups other than aminoacyl groups. The <a href="/facts/List_of_enzymes/w2RP6EwU">systematic name</a> of this enzyme class is acetyl-CoA:formate C-acetyltransferase. Other names in common use include pyruvate formate-lyase, pyruvic formate-lyase, and formate acetyltransferase. This enzyme participates in 3 <a href="/facts/Metabolism/WxDrm8k5">metabolic pathways</a>: <a href="/facts/Pyruvate_metabolism/qJTgl4J9">pyruvate metabolism</a>, <a href="/facts/Propanoate_metabolism/ugBEw0Ia">propanoate metabolism</a>, and <a href="/facts/Butanoate_metabolism/Sy5NrhK5">butanoate metabolism</a>. </p>