TRNA (cytidine34-2'-O)-methyltransferase

tRNA (cytidine34-2'-O)-methyltransferase (<a href="/facts/Enzyme_Commission_number/Y5GNLRKX">EC</a> <a href="https://enzyme.expasy.org/EC/2.1.1.207">2.1.1.207</a>, yibK (gene), methyltransferase yibK, TrmL, tRNA methyltransferase L, tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase) is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> with <a href="/facts/List_of_enzymes/w2RP6EwU">systematic name</a> S-adenosyl-L-methionine:tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase. This enzyme <a href="/facts/Catalysis/LPBS7TQC">catalyses</a> the following <a href="/facts/Chemical_reaction/GpqWlKrz">chemical reaction</a>

(1) <a href="/facts/S-adenosyl-L-methionine/oAsJ0SSR">S-adenosyl-L-methionine</a> + <a href="/facts/Cytidine/6HmUSFvk">cytidine</a>34 in <a href="/facts/Transfer_RNA/pR9T5XSl">tRNA</a> 
 
 
 
 ⇌
 
 
 {\displaystyle \rightleftharpoons }
 
 <a href="/facts/S-adenosyl-L-homocysteine/qejSLwMv">S-adenosyl-L-homocysteine</a> + 2'-O-methylcytidine34 in tRNA
(2) S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine34 in tRNALeu 
 
 
 
 ⇌
 
 
 {\displaystyle \rightleftharpoons }
 
 S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNALeu
The enzyme from <a href="/facts/Escherichia_coli/nR4Gvl56">Escherichia coli</a> catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a> 34 in tRNALeuCmAA and tRNALeucmnm5UmAA.

TRNA (cytidine34-2'-O)-methyltransferase open-in-new

TRNA (cytidine34-2'-O)-methyltransferase