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Codon Adaptation Index
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<p>The Codon Adaptation Index (CAI) is the most widespread technique for analyzing <a href="/facts/Codon_usage_bias/UfMw2mde">codon usage bias</a>. As opposed to other measures of codon usage bias, such as the '<a href="/facts/Effective_number_of_codons/tx6y4bKp">effective number of codons</a>' (Nc), which measure deviation from a uniform bias (null hypothesis), CAI measures the deviation of a given protein coding gene sequence with respect to a reference set of genes. CAI is used as a quantitative method of predicting the level of expression of a gene based on its codon sequence. </p>