6-Phosphogluconate dehydrogenase

<p>6-Phosphogluconate dehydrogenase (6PGD) is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> in the <a href="/facts/Pentose_phosphate_pathway/NbuG6Ffj">pentose phosphate pathway</a>. It forms <a href="/facts/Ribulose_5-phosphate/VnQ2Ngdt">ribulose 5-phosphate</a> from <a href="/facts/6-phosphogluconate/FXaf8169">6-phosphogluconate</a>:
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6-phospho-D-gluconate + NAD(P)+ 
  
    
      
        ⇌
      
    
    {\displaystyle \rightleftharpoons }
  
 D-Ribulose 5-phosphate + CO2 + NAD(P)H + H+
<p>It is an oxidative carboxylase that <a href="/facts/Catalysis/LPBS7TQC">catalyses</a> the <a href="/facts/Oxidative_decarboxylation/gpm1xB6n">oxidative decarboxylation</a> of <a href="/facts/6-phosphogluconate/FXaf8169">6-phosphogluconate</a> into <a href="/facts/Ribulose_5-phosphate/VnQ2Ngdt">ribulose 5-phosphate</a> in the presence of <a href="/facts/NADP/XMgmPQ5t">NADP</a>. This reaction is a component of the <a href="/facts/Hexose/ooxIWuDL">hexose</a> mono-phosphate shunt and <a href="/facts/Pentose_phosphate_pathway/NbuG6Ffj">pentose phosphate pathways</a> (PPP). <a href="/facts/Prokaryotic/oYyvaDDH">Prokaryotic</a> and <a href="/facts/Eukaryotic/SkwyPLMA">eukaryotic</a> 6PGD are <a href="/facts/Protein/Jxmagu3E">proteins</a> of about 470 <a href="/facts/Amino_acid/WDxYwBny">amino acids</a> whose <a href="/facts/Sequence_(biology)/JKT2Hh9s">sequences</a> are <a href="/facts/Conservation_(genetics)/YAxy2Xa2">highly conserved</a>. The protein is a <a href="/facts/Homodimer/c8LwFJPG">homodimer</a> in which the <a href="/facts/Monomer/Gw3CltMb">monomers</a> act independently: each contains a large, mainly <a href="/facts/Alpha_helix/7CESPIYJ">alpha-helical</a> <a href="/facts/Domain_(biology)/RpP6V7n6">domain</a> and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded <a href="/facts/Beta_sheet/B6mwwR6H">beta sheet</a>. NADP is bound in a cleft in the small domain, the <a href="/facts/Enzyme_substrate/6MnaV19h">substrate</a> <a href="/facts/Binding_(molecular)/cBnorUC5">binding</a> in an adjacent pocket.
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6-Phosphogluconate dehydrogenase open-in-new

6-Phosphogluconate dehydrogenase