CCL8

Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the CCL8 <a href="/facts/Gene/e1swwPY6">gene</a>.
CCL8 is a small <a href="/facts/Cytokine/SdWpWABH">cytokine</a> belonging to the CC <a href="/facts/Chemokine/YrySj9eD">chemokine</a> family. The CCL8 protein is produced as a <a href="/facts/Protein_precursor/A1vxb5mN">precursor</a> containing 109 <a href="/facts/Amino_acid/WDxYwBny">amino acids</a>, which is cleaved to produce mature CCL8 containing 75 amino acids. The <a href="/facts/Gene/e1swwPY6">gene</a> for CCL8 is encoded by 3 <a href="/facts/Exon/8KWJtLuN">exons</a> and is located within a large cluster of CC chemokines on <a href="/facts/Chromosome_17/SzAlnKTV">chromosome 17q</a>11.2 in humans. MCP-2 is <a href="/facts/Chemotaxis/hYPRdPTk">chemotactic</a> for and activates many different immune cells, including <a href="/facts/Mast_cell/szfXss5q">mast cells</a>, <a href="/facts/Eosinophil/yhIKA8bE">eosinophils</a> and <a href="/facts/Basophil/FRN1ugHk">basophils</a>, (that are implicated in <a href="/facts/Allergic/dYAVosh8">allergic</a> responses), and <a href="/facts/Monocyte/FW4NNMKM">monocytes</a>, <a href="/facts/T_cell/5z6PQ9UN">T cells</a>, and <a href="/facts/NK_cell/A3THWxrJ">NK cells</a> that are involved in the <a href="/facts/Inflammation/Ura86MIy">inflammatory</a> response. CCL8 elicits its effects by binding to several different cell surface receptors called <a href="/facts/Chemokine_receptor/pU0hsbnE">chemokine receptors</a>. These receptors include <a href="/facts/CC_chemokine_receptors/e6G8YoIj">CCR1</a>, <a href="/facts/CC_chemokine_receptors/e6G8YoIj">CCR2B</a>, <a href="/facts/CC_chemokine_receptors/e6G8YoIj">CCR3</a> and <a href="/facts/CC_chemokine_receptors/e6G8YoIj">CCR5</a>.
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of <a href="/facts/HIV1/vzeVgtKQ">HIV1</a> by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1. In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes. CCL8 is also involved in attracting macrophages to the decidua in labor.

CCL8 open-in-new

CCL8