Apixaban

Apixaban, sold under the brand name Eliquis, is an <a href="/facts/Anticoagulant/cARpjm0G">anticoagulant</a> medication used to treat and prevent <a href="/facts/Venous_thromboembolism/oQAalgo3">blood clots</a> and to prevent <a href="/facts/Stroke/DwpjdzY0">stroke</a> in people with nonvalvular <a href="/facts/Atrial_fibrillation/Rzkq1tmN">atrial fibrillation</a> through directly inhibiting <a href="/facts/Factor_Xa/7IQfSlKM">factor Xa</a>. It is used as an alternative to <a href="/facts/Warfarin/kMnH6tb0">warfarin</a> to prevent blood clots following <a href="/facts/Hip_replacement/YcdY8GGC">hip</a> or <a href="/facts/Knee_replacement/zmUkob0L">knee replacement</a> and in those with a history of prior clots and does not require monitoring by blood tests or dietary restrictions. It is taken <a href="/facts/Oral_administration/vNQcvLVx">by mouth</a>.
Common side effects include <a href="/facts/Bleeding/CGyFMU0F">bleeding</a> and nausea. Other side effects may include <a href="/facts/Spinal_hematoma/CVuALj53">bleeding around the spine</a> and allergic reactions. Use is not recommended during <a href="/facts/Pregnancy/vEKYGpep">pregnancy</a> or <a href="/facts/Breastfeeding/cdWXyYDX">breastfeeding</a>. Use appears to be relatively safe in those with mild <a href="/facts/Kidney_problems/gsqb5nos">kidney problems</a>. Compared to warfarin it has fewer <a href="/facts/Drug_interaction/T5VcSVGd">interactions with other medications</a>. It is a <a href="/facts/Direct_factor_Xa_inhibitor/jWsI4Dw9">direct factor Xa inhibitor</a>.
In 2007, <a href="/facts/Pfizer/1ADDanWs">Pfizer</a> and <a href="/facts/Bristol_Myers_Squibb/HK47xMNF">Bristol-Myers Squibb</a> began the development of apixaban as an anticoagulant. Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012. It is on the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">World Health Organization's List of Essential Medicines</a>. In 2022, it was the 27th most commonly prescribed medication in the United States, with more than 19 million prescriptions. It is available as a generic medication, although not in the United States.

Apixaban open-in-new

Apixaban