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Perls Prussian blue
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<p>In <a href="/facts/Histology/yrI90zlU">histology</a>, <a href="/facts/Histopathology/9Eggjrg4">histopathology</a>, and <a href="/facts/Clinical_pathology/S08jcRvc">clinical pathology</a>, Perls Prussian blue is a commonly used method to detect the presence of <a href="/facts/Iron/QK1JYy8E">iron</a> in tissue or cell samples.: 235 Perls Prussian Blue derives its name from the German pathologist Max Perls (1843–1881), who described the technique in 1867. The method does not involve the application of a dye but rather causes the pigment <a href="/facts/Prussian_blue/IV0VooPH">Prussian blue</a> to form directly within the tissue. The method stains mostly iron in the <a href="/facts/Ferric/TMrSskIt">ferric</a> state which includes <a href="/facts/Ferritin/w7G85xJg">ferritin</a> and <a href="/facts/Hemosiderin/egsBzVJK">hemosiderin</a>, rather than iron in the <a href="/facts/Ferrous/AGImjWqq">ferrous</a> state. </p>