Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
Bryostatin
open-in-new
<p>Bryostatins are a group of <a href="/facts/Macrolide/21qIKr7a">macrolide</a> <a href="/facts/Lactone/UMgRUFtj">lactones</a> from (bacterial symbionts of) the marine organism <i><a href="/facts/Bugula_neritina/kGsv3V5C">Bugula neritina</a></i> that were first collected and provided to JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by <a href="/facts/Jack_Rudloe/PuXV2evn">Jack Rudloe</a>. Bryostatins are potent modulators of <a href="/facts/Protein_kinase_C/6WSQgAWv">protein kinase C</a>. They have been studied in clinical trials as anti-<a href="/facts/Cancer/PVW6n1D0">cancer</a> agents, as anti-AIDS/HIV agents and in people with <a href="/facts/Alzheimer%2527s_disease/w7Ad6tdg">Alzheimer's disease</a>. </p>