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Serotonin releasing agent
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<p>A serotonin releasing agent (SRA) is a type of drug that induces the <a href="/facts/Releasing_agent/JwSvmyR8">release</a> of <a href="/facts/Serotonin/EzY58q4a">serotonin</a> into the neuronal <a href="/facts/Synaptic_cleft/M1x5rhz7">synaptic cleft</a>. A selective serotonin releasing agent (SSRA) is an SRA with less significant or no efficacy in producing <a href="/facts/Neurotransmitter/LlpYFSU3">neurotransmitter</a> efflux at other types of <a href="/facts/Monoamine/TduN5yes">monoamine</a> neurons, including <a href="/facts/Dopamine/5gNy8Xkd">dopamine</a> and <a href="/facts/Norepinephrine/AjTIC9ox">norepinephrine</a> neurons. </p><p>SRAs, for instance <a href="/facts/Fenfluramine/egSpgNxd">fenfluramine</a>, <a href="/facts/Dexfenfluramine/CPSAWSlG">dexfenfluramine</a>, and <a href="/facts/Chlorphentermine/e3P8lhBT">chlorphentermine</a>, have been used clinically as <a href="/facts/Appetite_suppressant/MuLF8GNo">appetite suppressants</a>. However, these SRAs were <a href="/facts/Withdrawn_drug/KC9vDrj7">withdrawn</a> from the market due to <a href="/facts/Toxicity/qa96rs60">toxicity</a> in the 1990s and no SRAs were available or employable for clinical study for many years. In any case, a low-dose formulation was reintroduced for treatment of <a href="/facts/Dravet_syndrome/H7lsoRUQ">Dravet syndrome</a> in 2020 and this allowed clinical and research use of SRAs in humans once again. </p><p>Aside from use as appetite suppressants, SSRAs have been proposed as novel <a href="/facts/Antidepressant/N62ND3Fa">antidepressants</a> and <a href="/facts/Anxiolytic/uEWpGca9">anxiolytics</a>, with the potential for a faster <a href="/facts/Onset_of_action/BTIWvLSY">onset of action</a> and superior <a href="/facts/Effectiveness/L8yAf41P">effectiveness</a> relative to the <a href="/facts/Selective_serotonin_reuptake_inhibitor/L6jjcmEH">selective serotonin reuptake inhibitors</a> (SSRIs). </p><p>A closely related type of drug is a <a href="/facts/Serotonin_reuptake_inhibitor/aAWCuaD5">serotonin reuptake inhibitor</a> (SRI), for instance <a href="/facts/Fluoxetine/U28lM3Pm">fluoxetine</a>. </p>