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Substituted mescaline analogue
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<p>A substituted mescaline analogue, also known as a scaline and typically but not always a 4-substituted 3,5-dimethoxyphenethylamine, is an <a href="/facts/Structural_analog/3aysWSVG">analogue</a> of the <a href="/facts/Substituted_phenethylamine/dte6TQxS">phenethylamine</a> <a href="/facts/Serotonergic_psychedelic/oyp10dgE">serotonergic psychedelic</a> <a href="/facts/Mescaline/Y6gXHD9T">mescaline</a> (3,4,5-trimethoxyphenethylamine). </p><p>Other related compounds include the <a href="/facts/2C_(psychedelics)/CwHza8Wg">2C</a> (4-substituted 2,5-dimethoxyphenethylamine) and <a href="/facts/DOx/CDyDzyL8">DOx</a> (4-substituted 2,5-dimethoxyamphetamine) <a href="/facts/Chemical_compound/37FXqqtv">compounds</a> as well as <a href="/facts/3,4,5-trimethoxyamphetamine/XsRnGhAY">3,4,5-trimethoxyamphetamine</a> (TMA) and other 4-substituted 3,5-dimethoxyamphetamines (3C drugs). They are also mescaline analogues, but the 2C and DOx drugs have a third methoxy group in the 2 position instead of the 3 position while TMA is an <a href="/facts/Substituted_amphetamine/KlmrodPb">amphetamine</a> rather than a phenethylamine. </p><p>The <a href="/facts/Pharmacology/4Rx8s7Ie">pharmacology</a> of mescaline analogues has been studied. Mescaline analogues, or 4-substituted 3,5-dimethoxyphenethylamines specifically, tend to be much less <a href="/facts/Potency_(pharmacology)/D38FDyPh">potent</a> than the 2C and DOx drugs. This relates to the fact that the 2,4,5-substitution pattern tends to be optimal in terms of <a href="/facts/Affinity_(pharmacology)/44QLL4eU">receptor affinity</a> and potency. However, mescaline analogues are not infrequently much more potent than mescaline. </p><p>Substituted mescaline analogues have been extensively characterized by <a href="/facts/Alexander_Shulgin/DK7CAPtu">Alexander Shulgin</a> and described in his books such as <i><a href="/facts/PiHKAL/sAR8owwC">PiHKAL</a></i> (<i>Phenethylamines I Have Known and Loved</i>) and <i><a href="/facts/The_Shulgin_Index,_Volume_One:_Psychedelic_Phenethylamines_and_Related_Compounds/bevcka9e">The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds</a></i> as well as in his <a href="/facts/Literature_review/SIE3DITr">literature reviews</a>. They have also been studied by <a href="/facts/David_E._Nichols/aLlPrQ9V">David E. Nichols</a> and <a href="/facts/Daniel_Trachsel/JNP3yXLh">Daniel Trachsel</a>, among other researchers. </p>