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Reference.org
SPN1
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<p>Snurportin1 is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the <i>SNUPN</i> <a href="/facts/Gene/e1swwPY6">gene</a>. </p><p>The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U <a href="/facts/SnRNA/6XKVBBJM">snRNA</a> and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. </p>