NF-κB

<p>Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of <a href="/facts/Transcription_factor/wro0DPHe">transcription factor</a> <a href="/facts/Protein_complex/GW11Ee34">protein complexes</a> that controls <a href="/facts/Transcription_(genetics)/bDgp9HDN">transcription</a> of <a href="/facts/DNA/nB89Iauz">DNA</a>, <a href="/facts/Cytokine/SdWpWABH">cytokine</a> production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, <a href="/facts/Cytokine/SdWpWABH">cytokines</a>, <a href="/facts/Free_radical/qFymuVoT">free radicals</a>, <a href="/facts/Heavy_metals/Cblmy8qI">heavy metals</a>, <a href="/facts/Ultraviolet_irradiation/kncBUqn5">ultraviolet irradiation</a>, oxidized <a href="/facts/LDL/R5VLPxAg">LDL</a>, and bacterial or viral <a href="/facts/Antigen/9JlAernG">antigens</a>. NF-κB plays a key role in regulating the <a href="/facts/Immune_response/dtLulqIy">immune response</a> to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and <a href="/facts/Autoimmune_diseases/sojBeQ7t">autoimmune diseases</a>, <a href="/facts/Septic_shock/yc9mgmrz">septic shock</a>, <a href="/facts/Viral_infection/F1Tth6qP">viral infection</a>, and improper immune development. NF-κB has also been implicated in processes of <a href="/facts/Synaptic_plasticity/rdVFxItN">synaptic plasticity</a> and memory.
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NF-κB open-in-new

NF-κB