Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
Adenosine thiamine triphosphate
open-in-new
<p>Adenosine thiamine triphosphate (AThTP), or thiaminylated adenosine triphosphate, is a natural <a href="/facts/Thiamine/37RC4MCS">thiamine</a> <a href="/facts/Adenine/PSeDFBnl">adenine</a> <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a>. It was discovered in <i><a href="/facts/Escherichia_coli/nR4Gvl56">Escherichia coli</a></i> where it may account for up to 15 - 20% of total thiamine under carbon starvation. AThTP also exists in <a href="/facts/Eukaryote/SkwyPLMA">eukaryotic</a> organisms such as yeast, roots of higher plants and animal tissues, albeit at a much lower concentration. It was found to exist in small amounts in the muscle, heart, brain, kidneys and liver of mice. </p><p>In <i>E. coli</i> AThTP is synthesized from <a href="/facts/Thiamine_diphosphate/xGQAGmhC">thiamine diphosphate</a> (ThDP) according to the following reaction catalyzed by thiamine diphosphate adenylyl transferase: </p> ThDP + ATP (ADP) ↔ AThTP + PPi (Pi)