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Probucol
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<p>Probucol, sold under the trade name Lorelco among others, is an <a href="/facts/Lipid-lowering_agent/5vnk3W0m">lipid-lowering agent</a> initially developed for the treatment of <a href="/facts/Coronary_artery_disease/szCt0nVx">coronary artery disease</a>. Clinical use was discontinued in some countries after it was found that the drug may have the undesired effect of lowering <a href="/facts/High-density_lipoprotein/x7cs1ys9">HDL-C</a> in patients with a previous history of heart disease. It may also cause <a href="/facts/Drug-induced_QT_prolongation/20RJGMJ8">QT interval prolongation</a>. </p><p>Probucol was originally developed as an industrial antioxidant added to tires to maximize their longevity. </p>