Zbtb7

Zbtb7, whose protein product is also known as Pokemon, is a <a href="/facts/Gene/e1swwPY6">gene</a> that functions as a regulator of cellular growth and a <a href="/facts/Proto_oncogene/WLFu6Ma5">proto oncogene</a>.
Zbtb7 is a member of the POK (POZ and Krüppel) family of genes, and the ZBTB protein family that contains <a href="/facts/Zinc_finger/dWrlw4t7">zinc finger</a> and <a href="/facts/BTB/POZ_domain/HNr3vB4g">BTB</a> domains. It is also known as LRF10 (leukemia/lymphoma-related factor), OCZF11 (osteoclast-derived zinc finger), and FBI1 (1-3) (fourteen-three-three beta interactant).
Zbtb7 is a <a href="/facts/Transcription_factor/wro0DPHe">transcription factor</a> that regulates pathways involved in cell growth and <a href="/facts/Transcription_(biology)/bDgp9HDN">transcription</a> and it specifically represses many activities. When this gene binds to a <a href="/facts/Consensus_sequence/StFdcuTb">consensus sequence</a>, it prevents transcription by controlling the conformation of <a href="/facts/Chromatin/ha0TJheJ">chromatin</a> and bringing other transcription factors to gene regulation sites. This gene controls access to gene transcription regulation regions. Zbtb7 prevents <a href="/facts/Sp1_transcription_factor/Tz4tCgbE">SP1</a>, a transcription factor, from binding to DNA which will halt the process of transcribing DNA to RNA. Downstream effects of Zbtb7 activity include failure to transcribe ARF, a critical tumor suppressor. Zbtb7 is also involved in the regulation of p53, another tumor suppressor gene. As an oncogene, Zbtb7 is overexpressed in many types of cancer, including lung, liver, prostate, and oral.

Zbtb7 open-in-new

Zbtb7