B recognition element

<p>The B recognition element (BRE) is a <a href="/facts/DNA_sequence/hsPsNCQW">DNA sequence</a> found in the <a href="/facts/Promoter_region/YDYBzLfg">promoter region</a> of most genes in <a href="/facts/Eukaryote/SkwyPLMA">eukaryotes</a> and <a href="/facts/Archaea/Adxh0aHw">Archaea</a>.  The BRE is a <a href="/facts/Cis-regulatory_element/q6u6VSBs">cis-regulatory element</a> that is found immediately near <a href="/facts/TATA_box/GFu8tHxH">TATA box</a>, and consists of 7 <a href="/facts/Nucleotide/pQKEwlJI">nucleotides</a>. There are two sets of BREs: one (BREu) found immediately upstream of the TATA box, with the consensus SSRCGCC; the other (BREd) found around 7 nucleotides downstream, with the consensus RTDKKKK.
</p><p>The BREu was discovered in 1998 by <a href="/facts/Richard_H._Ebright/jQYB8aNF">Richard Ebright</a> and co-workers. The BREd was named in 2005 by Deng and Roberts; such a downstream recognition was reported earlier in 2000 in Tsai and Sigler's crystal structure.
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B recognition element open-in-new

B recognition element