Nocodazole

Nocodazole is an <a href="/facts/Antineoplastic_agent/fWTLbaUT">antineoplastic agent</a> which exerts its effect in cells by interfering with the <a href="/facts/Polymer/eF32E50K">polymerization</a> of <a href="/facts/Microtubule/ENL1TxSe">microtubules</a>. Microtubules are one type of fibre which constitutes the <a href="/facts/Cytoskeleton/1sWlJRX9">cytoskeleton</a>, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the <a href="/facts/Mitotic_spindle/FMFd1GM5">mitotic spindle</a> and in <a href="/facts/Cytokinesis/hhrnmTwY">cytokinesis</a>. Several drugs including <a href="/facts/Vincristine/GJWrGMkH">vincristine</a> and <a href="/facts/Colcemid/dWlp0JTz">colcemid</a> are similar to nocodazole in that they interfere with microtubule polymerization.
Nocodazole has been shown to decrease the oncogenic potential of cancer cells via another microtubules-independent mechanisms. Nocodazole stimulates the expression of <a href="/facts/LATS2/fxTrg1Yj">LATS2</a> which potently inhibits the <a href="/facts/Wnt_signaling_pathway/7wxpKrjy">Wnt signaling pathway</a> by abrogating the interaction between the Wnt-dependent transcriptional co-factors <a href="/facts/Beta-catenin/5eQzonk1">beta-catenin</a> and <a href="/facts/BCL9/cRefBASM">BCL9</a>.
It is related to <a href="/facts/Mebendazole/b0sMTV1e">mebendazole</a> by replacement of the left most benzene ring by <a href="/facts/Thiophene/pQhcmsCK">thiophene</a>.

Nocodazole open-in-new

Nocodazole