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Ceftaroline fosamil
open-in-new
<p>Ceftaroline fosamil (<a href="/facts/International_Nonproprietary_Name/wYL655x6">INN</a>) /sɛfˈtæroʊliːn/, brand name Teflaro in the US and Zinforo in Europe, is a <a href="/facts/Cephalosporin/WeB7I75T">cephalosporin</a> <a href="/facts/Antibiotic/sF1kIfxg">antibiotic</a> with anti-MRSA activity. Ceftaroline fosamil is a prodrug of ceftaroline. It is active against <a href="/facts/Methicillin-resistant_Staphylococcus_aureus/4DGUo2co">methicillin-resistant <i>Staphylococcus aureus</i></a> (MRSA) and other <a href="/facts/Gram-positive/H6WYQ17e">Gram-positive</a> bacteria. It retains some activity of later-generation cephalosporins having broad-spectrum activity against <a href="/facts/Gram-negative/S1PbVtp4">Gram-negative</a> bacteria, but its effectiveness is relatively much weaker. It is currently being investigated for <a href="/facts/Community-acquired_pneumonia/kmP37hGa">community-acquired pneumonia</a> and <a href="/facts/Complicated_skin_and_skin_structure_infection/UWn7FHFT">complicated skin and skin structure infection</a>. </p><p>Ceftaroline is being developed[<i>when?</i>] by <a href="/facts/Forest_Laboratories/1WQ4JCeV">Forest Laboratories</a>, under a license from <a href="/facts/Takeda_Pharmaceutical_Company/nkX8WYAs">Takeda</a>. Ceftaroline received approval from the U.S. <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) for the treatment of community-acquired bacterial <a href="/facts/Pneumonia/Jw0KquTA">pneumonia</a> and acute bacterial skin infections on 29 October 2010. <i>In vitro</i> studies show it has a similar spectrum to <a href="/facts/Ceftobiprole/kDVb7BrT">ceftobiprole</a>,[<i>not verified in body</i>] the only other fifth-generation cephalosporin to date,[<i>when?</i>] although no head-to-head clinical trials have been conducted. Ceftaroline and ceftobiprole are on an unnamed subclass of cephalosporins by the <a href="/facts/Clinical_and_Laboratory_Standards_Institute/b5acraIz">Clinical and Laboratory Standards Institute</a> (CLSI).[<i>not verified in body</i>] </p><p>It was removed from the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">World Health Organization's List of Essential Medicines</a> in 2019. </p>