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QM/MM
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<p> The hybrid QM/MM (<a href="/facts/Quantum_mechanics/BRc3Mzgr">quantum mechanics</a>/<a href="/facts/Molecular_mechanics/6wPpARWP">molecular mechanics</a>) approach is a molecular <a href="/facts/Simulation/Q4QJV1oI">simulation</a> method that combines the strengths of <a href="/facts/Ab_initio_quantum_chemistry_methods/Rwuu2At1"><i>ab initio</i> QM calculations</a> (accuracy) and MM (speed) approaches, thus allowing for the study of chemical processes in solution and in proteins. The QM/MM approach was introduced in the 1976 paper of <a href="/facts/Arieh_Warshel/GFdpNtAN">Warshel</a> and <a href="/facts/Michael_Levitt_(biophysicist)/4plxcQ5D">Levitt</a>. They, along with <a href="/facts/Martin_Karplus/HG9KtXIf">Martin Karplus</a>, won the 2013 <a href="/facts/Nobel_Prize_in_Chemistry/8Nb8Ajjy">Nobel Prize in Chemistry</a> for "the development of multiscale models for complex chemical systems". </p>