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FoldX
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<p>FoldX is a <a href="/facts/Molecular_design_software/BsLuzcbr">protein design</a> algorithm that uses an empirical <a href="/facts/Force_field_(chemistry)/p9u8nVk8">force field</a>. It can determine the energetic effect of point <a href="/facts/Mutations/Ee4NnWbY">mutations</a> as well as the <a href="/facts/Interaction_energy/gkEdCDux">interaction energy</a> of <a href="/facts/Protein/Jxmagu3E">protein</a> complexes (including Protein-<a href="/facts/DNA/nB89Iauz">DNA</a>). FoldX can mutate protein and DNA side chains using a probability-based <a href="/facts/Rotamer/JflrT5Ws">rotamer library</a>, while exploring alternative conformations of the surrounding side chains. </p>