Oleandrin is a cardiac glycoside found in the poisonous plant oleander (Nerium oleander L.). As a main phytochemical of oleander, oleandrin is associated with the toxicity of oleander sap, and has similar properties to digoxin. Oleandrin and other oleander chemicals are potentially toxic to the heart, liver, and kidneys.
Although oleander has been used in traditional medicine and as a dietary supplement, there is no clinical evidence that oleander and its constituents, including oleandrin, are safe or effective for any therapeutic purpose. Oleandrin is not approved by regulatory agencies as a prescription drug.