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Reference.org
Spatial transcriptomics
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<p> Spatial transcriptomics, or spatially resolved transcriptomics, is a method that captures positional context of transcriptional activity within intact tissue. The historical precursor to spatial transcriptomics is <a href="/facts/In_situ_hybridization/RFKJedCS"><i>in situ</i> hybridization</a>, where the modernized <a href="/facts/Omics/e1KybBYT">omics</a> terminology refers to the measurement of all the mRNA in a cell rather than select RNA targets. It comprises an important part of <a href="/facts/Spatial_biology/KaDDQLFk">spatial biology</a>. </p><p>Spatial transcriptomics includes methods that can be divided into two modalities, those based in next-generation sequencing for gene detection, and those based in imaging. Some common approaches to resolve spatial distribution of transcripts are microdissection techniques, fluorescent <i>in situ</i> hybridization methods, <i>in situ</i> sequencing, <i>in situ</i> capture protocols and <i>in silico</i> approaches. </p>