Phosphoramidate

<p>In <a href="/facts/Organophosphorus_chemistry/kNgIF93U">organophosphorus chemistry</a>, phosphoramidates (sometimes also called amidophosphates) are a class of <a href="/facts/Phosphorus/27xCeIqs">phosphorus</a> compounds structurally related to <a href="/facts/Phosphate/FDGVCxUG">phosphates</a> (or <a href="/facts/Organophosphate/u4U9GS4z">organophosphates</a>) via the substitution of an −O− group for an <a href="/facts/Amine_group/SN7W44fv">amine group</a> (−N−). They are <a href="/facts/Derivative_(chemistry)/JYcbLkbm">derivatives</a> of phosphoramidic acids, which possess the structure O=P(OH)(NR2)2 or O=P(OH)2(NR2).
</p><p>A <a href="/facts/Diamidophosphate/KplvWUzW">phosphorodiamidate</a> is a phosphate that has two of its <a href="/facts/Hydroxyl/1Hs2QAEv">hydroxyl</a> (−OH) groups substituted by amine (NR2) groups to give a species with the general formula O=P(OH)(NH2)2.  The substitution of all three OH groups gives the phosphoric triamides (O=P(NR2)3), which are commonly referred to as <a href="/facts/Phosphoramides/0fvKIHDk">phosphoramides</a>.
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Phosphoramidate open-in-new

Phosphoramidate