CRISPR RNA

<p>CRISPR RNA or crRNA is a <a href="/facts/RNA_transcript/bDgp9HDN">RNA transcript</a> from the CRISPR locus. <a href="/facts/CRISPR-Cas/VqRDofqC">CRISPR-Cas</a> (clustered, regularly interspaced short palindromic repeats - CRISPR associated systems) is an adaptive immune system found in <a href="/facts/Bacteria/wC8xSCsU">bacteria</a> and <a href="/facts/Archaea/Adxh0aHw">archaea</a> to protect against <a href="/facts/Mobile_genetic_elements/cmVCkbA7">mobile genetic elements</a>, like <a href="/facts/Virus/mf88Bcbl">viruses</a>, <a href="/facts/Plasmid/yf59JVlA">plasmids</a>, and <a href="/facts/Transposable_element/WbVMhuWR">transposons</a>. The CRISPR locus contains a series of repeats interspaced with unique spacers. These unique spacers can be acquired from <a href="/facts/Mobile_genetic_elements/cmVCkbA7">MGEs</a>.
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<p>Pre-crRNA is formed after the transcription of the CRISPR locus and before being processed by Cas proteins. Mature crRNA transcripts contain a partial conserved section of repeat and a sequence of spacer that is complementary to the target DNA. crRNA forms an effector complex with a single nuclease or multiple Cas proteins called a Cascade (CRISPR-associated complex for antiviral defense).  Once the effector complex is formed a Cas <a href="/facts/Nuclease/79mnW28W">nuclease</a> or single effector protein will cause interference guided by the crRNA match.
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CRISPR RNA open-in-new

CRISPR RNA