3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH). It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.
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References
Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 789 (2): 111–8. doi:10.1016/0167-4838(84)90194-8. PMID 6148105. /wiki/Doi_(identifier) ↩