Castellucci is an Italian surname. Notable people with the surname include:

• Cecil Castellucci (born 1969), American-born Canadian young adult novelist, indie rocker and director
• Eugenio Castellucci, Argentine professional football player
• Giovanni Castellucci (born 1959), Italian businessman
• Lars Castellucci (born 1974), German politician
• Romeo Castellucci (born 1960), Italian theater director, playwright, artist and designer
• Salvi Castellucci (1608–1672), Italian painter
• Teddy Castellucci (born 1965), American film score composer