Menu
Home Explore People Places Arts History Plants & Animals Science Life & Culture Technology
On this page
DPH1
Protein-coding gene in the species Homo sapiens

Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene. It encodes a protein that performs posttranslational modification of histidine-715 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.

Related Image Collections Add Image
We don't have any YouTube videos related to DPH1 yet.
We don't have any PDF documents related to DPH1 yet.
We don't have any Books related to DPH1 yet.
We don't have any archived web articles related to DPH1 yet.

Further reading

References

  1. Phillips NJ, Zeigler MR, Deaven LL (May 1996). "A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3". Cancer Lett. 102 (1–2): 85–90. doi:10.1016/0304-3835(96)04169-9. PMID 8603384. https://zenodo.org/record/1258459

  2. Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol. 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC522255

  3. "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1801

  4. Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ (2008). "Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development". J. Cell Sci. 121 (Pt 19): 3140–5. doi:10.1242/jcs.035550. PMC 2592597. PMID 18765564. Diphthamide modification is present in all eukaryotic organisms, in which it is restricted to a histidine residue of translation elongation factor 2 (eEF2, also known as EFT1; position 715 in mammals and 699 in yeast) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592597