Dysidazirine is an organic compound with formula C19H33NO2. It was discovered as a natural product in 1988 in the marine sponge Dysidea fragilis. Chemically, it is a 2H-azirine derivative.
Dysidazirine synthesis was reported for the first time in 1995.
Dysidazirine kills the yeasts Candida albicans and Sacharamyces cerevisiae in vitro. It also stops HCT-116 human colon cancer cells from growing.
References
"Despite my high ring strain, I'm pretty stable. What molecule am I?". ACS.org. American Chemical Society. Retrieved 18 November 2022. https://www.acs.org/content/acs/en/molecule-of-the-week/archive/d/r-dysidazirine.html ↩
Davis, Franklin A.; Reddy, G. Venkat; Liu, Hu (1995). "Asymmetric Synthesis of 2H-Azirines: First Enantioselective Synthesis of the Cytotoxic Antibiotic (R)-(-)-Dysidazirine". Journal of the American Chemical Society. 117 (12): 3651–3652. doi:10.1021/ja00117a050. /wiki/Doi_(identifier) ↩
Skepper, Colin K.; Dalisay, Doralyn S.; Molinski, Tadeusz F. (2008). "Synthesis and Antifungal Activity of (−)-(Z)-Dysidazirine". Organic Letters. 10 (22): 5269–5271. doi:10.1021/ol802065d. PMC 2635126. PMID 18937483. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635126 ↩
"Despite my high ring strain, I'm pretty stable. What molecule am I?". ACS.org. American Chemical Society. Retrieved 18 November 2022. https://www.acs.org/content/acs/en/molecule-of-the-week/archive/d/r-dysidazirine.html ↩