Menu
Home Explore People Places Arts History Plants & Animals Science Life & Culture Technology
On this page
Ethinylestradiol/norethisterone acetate
Pharmaceutical combination

Ethinylestradiol/norethisterone acetate (EE/NETA), or ethinylestradiol/norethindrone acetate, is a combination of ethinylestradiol (EE) and norethisterone acetate (NETA) which is used as birth control and menopausal hormone therapy. EE is an estrogen, while norethisterone acetate (NETA) is a progestin. It is taken by mouth. Some preparations of EE/NETA used in birth control additionally contain an iron supplement in the form of ferrous fumarate.

Norethindrone acetate and ethinyl estradiol have been approved in the US for the prevention of pregnancy as a swallowable tablet since 1968. In 2022, the combination of ethinylestradiol with norethisterone or with norethisterone acetate was the 80th most commonly prescribed medication in the United States, with more than 8 million prescriptions. It is available as a generic medication.

We don't have any images related to Ethinylestradiol/norethisterone acetate yet.
We don't have any YouTube videos related to Ethinylestradiol/norethisterone acetate yet.
We don't have any PDF documents related to Ethinylestradiol/norethisterone acetate yet.
We don't have any Books related to Ethinylestradiol/norethisterone acetate yet.
We don't have any archived web articles related to Ethinylestradiol/norethisterone acetate yet.

Medical uses

Ethinylestradiol/norethisterone acetate is indicated for use by females of reproductive potential to prevent pregnancy.10

Ethinylestradiol/norethisterone acetate is also indicated in women with an intact uterus for the treatment of moderate to severe vasomotor symptoms associated with the menopause; and for prevention of postmenopausal osteoporosis.111213

Society and culture

Legal status

In July 2024, the US Food and Drug Administration (FDA) approved Femlyv, the first orally disintegrating tablet for the prevention of pregnancy.14 Norethindrone acetate and ethinyl estradiol have been approved in the US for the prevention of pregnancy as a swallowable tablet since 1968.15

Brand names

Brand names include Anovlar, Blisovi, Cumorit, Estrostep, Femhrt, Femlyv, Fyavolv, Gildess, Junel,16 Larin, Leribane, Loestrin, Lo Loestrin (Lo Lo), Mibelas, Microgestin, Minastrin, Norlestrin, Primodos, Taytulla, and Tri-Legest, among others.1718

See also

References

  1. "Estrogen-Progestin Combinations Monograph for Professionals". Drugs.com. AHFS. Retrieved 28 December 2018. https://www.drugs.com/monograph/estrogen-progestin-combinations.html ↩

  2. Rowan JP, Simon JA, Speroff L, Ellman H (June 2006). "Effects of low-dose norethindrone acetate plus ethinyl estradiol (0.5 mg/2.5 microg) in women with postmenopausal symptoms: updated analysis of three randomized, controlled trials". Clin Ther. 28 (6): 921–32. doi:10.1016/j.clinthera.2006.06.013. PMID 16860174. /wiki/Doi_(identifier) ↩

  3. "Estrogen-Progestin Combinations Monograph for Professionals". Drugs.com. AHFS. Retrieved 28 December 2018. https://www.drugs.com/monograph/estrogen-progestin-combinations.html ↩

  4. "Estrogen-Progestin Combinations Monograph for Professionals". Drugs.com. AHFS. Retrieved 28 December 2018. https://www.drugs.com/monograph/estrogen-progestin-combinations.html ↩

  5. Willihnganz M, Clayton AD (1 May 2014). Basic Pharmacology for Nurses - E-Book. Elsevier Health Sciences. pp. 648–. ISBN 978-0-323-29309-9. 978-0-323-29309-9 ↩

  6. "FDA Roundup: July 23, 2024". U.S. Food and Drug Administration (FDA) (Press release). 23 July 2024. Retrieved 25 July 2024. This article incorporates text from this source, which is in the public domain. https://www.fda.gov/news-events/press-announcements/fda-roundup-july-23-2024 ↩

  7. "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024. https://clincalc.com/DrugStats/Top300Drugs.aspx ↩

  8. "Ethinyl Estradiol; Norethindrone Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024. https://clincalc.com/DrugStats/Drugs/EthinylEstradiolNorethindrone ↩

  9. "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023. https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals ↩

  10. "Femlyv Full Prescribing Information" (PDF). Food and Drug Administration. Retrieved 17 January 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/218718s000lbl.pdf ↩

  11. Rowan JP, Simon JA, Speroff L, Ellman H (June 2006). "Effects of low-dose norethindrone acetate plus ethinyl estradiol (0.5 mg/2.5 microg) in women with postmenopausal symptoms: updated analysis of three randomized, controlled trials". Clin Ther. 28 (6): 921–32. doi:10.1016/j.clinthera.2006.06.013. PMID 16860174. /wiki/Doi_(identifier) ↩

  12. "Femhrt- norethindrone acetate/ethinyl estradiol tablet". DailyMed. 14 November 2017. Retrieved 31 December 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0fece0aa-2b9c-40a3-975e-1ef2c2ef72f2 ↩

  13. "Drug Approval Package: Femhrt (Norethindrone Acetate & Ethinyl Estradiol) NDA #21065". U.S. Food and Drug Administration (FDA). Retrieved 28 December 2018. https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/21065_Femhrt.cfm ↩

  14. "FDA Roundup: July 23, 2024". U.S. Food and Drug Administration (FDA) (Press release). 23 July 2024. Retrieved 25 July 2024. This article incorporates text from this source, which is in the public domain. https://www.fda.gov/news-events/press-announcements/fda-roundup-july-23-2024 ↩

  15. "FDA Roundup: July 23, 2024". U.S. Food and Drug Administration (FDA) (Press release). 23 July 2024. Retrieved 25 July 2024. This article incorporates text from this source, which is in the public domain. https://www.fda.gov/news-events/press-announcements/fda-roundup-july-23-2024 ↩

  16. "Junel 21 Day- norethindrone acetate and ethinyl estradiol tablet; Junel Fe 28 Day- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed. 14 August 2023. Retrieved 27 February 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b82ad14-580c-4145-b825-dce849f95363 ↩

  17. "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023. https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals ↩

  18. "Ethinyl Estradiol and Norethindrone (Professional Patient Advice)". Drugs.com. 13 July 2019. Retrieved 10 April 2020. https://www.drugs.com/ppa/ethinyl-estradiol-and-norethindrone.html ↩