Ethenzamide (2-ethoxybenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. It is also an ingredient in numerous cold medications and many prescription analgesics. It is used as an over-the-counter drug in Japan, often in combination with caffeine and acetaminophen, where it is marketed for uses including toothache, menstrual cramps, headache, and fever.
It is metabolized in vivo into salicylamide.
References
Darias V, Bravo L, Abdallah SS, Sánchez Mateo CC, Expósito-Orta MA, Lissavetsky J, Manzanares J (February 1992). "Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide". Archiv der Pharmazie. 325 (2): 83–7. doi:10.1002/ardp.19923250206. PMID 1605721. S2CID 28098596. /wiki/Doi_(identifier) ↩
Wang PJ, Guo HR (2004). "Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs". The Journal of Headache and Pain. 5 (1): 30–35. doi:10.1007/s10194-004-0065-x. PMC 3452147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452147 ↩
"OTC Pain Relief Medicine in Japan". Life Abroad. Retrieved March 22, 2021. https://lifeabroad.jp/html/medical_health/pain_relief.html ↩
"エテンザミド" [Ethenzamide] (in Japanese). Retrieved March 22, 2021. http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/mhiramt/EText/Diseases_Drugs/ethenzamide.htm ↩