Hydroxy can refer to:

• In chemical nomenclature, the prefix "hydroxy-" shows the presence of a hydroxyl functional group (−OH).
• An abbreviation for the medication hydroxyzine, which is commonly sold under the brand names Atarax, Ucerax, Serecid, and Vistaril.
• Hydroxy gas, a nickname for oxyhydrogen, a combination of hydrogen and oxygen gas produced from the electrolysis of water.