IEEE/ACM Transactions on Computational Biology and Bioinformatics (abbreviated TCBB) is a bimonthly peer-reviewed scientific journal. It is a joint publication of the IEEE Computer Society, Association for Computing Machinery (ACM), IEEE Computational Intelligence Society (CIS), and the IEEE Engineering in Medicine and Biology Society. It is published in cooperation with the IEEE Control Systems Society.

The journal covers research related to:

• algorithmic, mathematical, statistical, and computational methods used in bioinformatics and computational biology
• development and testing of effective computer programs in bioinformatics
• development and optimization of biological databases
• biological results that are obtained from the use of these methods, programs, and databases
• the field of systems biology