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LEFTY2
Protein-coding gene in the species Homo sapiens

Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans.

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Function

Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.23 It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.

Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).4 Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.

Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Further reading

  • Tabibzadeh S, Kothapalli R, Buyuksal I (1997). "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. doi:10.2741/a158. PMID 9230066.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

References

  1. "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19. https://www.ncbi.nlm.nih.gov/gene/7044 ↩

  2. GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody". www.genecards.org. Archived from the original on 2021-12-15. Retrieved 2025-04-03. http://web.archive.org/web/20211215082321/https://www.genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2 ↩

  3. "LEFTY2 left-right determination factor 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-04-03. https://www.ncbi.nlm.nih.gov/gene/7044 ↩

  4. GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody". www.genecards.org. Archived from the original on 2021-12-15. Retrieved 2025-04-03. http://web.archive.org/web/20211215082321/https://www.genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2 ↩