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LSU rRNA
One of the two major RNA components of the ribosome

Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome. Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.

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Characteristics

Characteristics of the LSU rRNA for exemplary species.
TypeLSU rRNA sizeSpeciesLengthAccessionReference
Bacterial (Prokaryotic)23SEscherichia coli2,905 ntNR_076322.11
Archaeal (Prokaryotic)23SHalobacterium salinarum2,906 ntNR_076247.12
Eukaryotic5.8S & 28SHomo sapiens157 + 5,025 ntNR_145821.1; M11167.134
Mitochondrial16SHomo sapiens1,559 ntNC_012920.156
Plastid23SArabidopsis thaliana2,810 ntNC_000932.17

Use in phylogenetics

LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.

See also

  • SSU rRNA: the small subunit ribosomal ribonucleic acid.

References

  1. "Escherichia coli 23S ribosomal RNA". 3 February 2015. https://www.ncbi.nlm.nih.gov/nuccore/NR_076322.1 ↩

  2. "Halobacterium salinarum 23S ribosomal RNA". 3 February 2015. https://www.ncbi.nlm.nih.gov/nuccore/NR_076247.1 ↩

  3. "Homo sapiens RNA, 5.8S ribosomal N1 (RNA5-8SN1), ribosomal RNA". 3 July 2020. https://www.ncbi.nlm.nih.gov/nuccore/NR_145821.1 ↩

  4. "Homo sapiens 28S ribosomal RNA (nuclear)". 10 November 1986. https://www.ncbi.nlm.nih.gov/nuccore/M11167.1 ↩

  5. Homo sapiens mitochondrion, complete genome. "Revised Cambridge Reference Sequence (rCRS): accession NC_012920", National Center for Biotechnology Information. Retrieved on 20 February 2017. https://www.ncbi.nlm.nih.gov/nuccore/NC_012920.1 ↩

  6. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature. 290 (5806): 457–465. Bibcode:1981Natur.290..457A. doi:10.1038/290457a0. PMID 7219534. /wiki/Bibcode_(identifier) ↩

  7. "Arabidopsis thaliana 23S ribosomal RNA (chloroplast)". 3 April 2023. https://www.ncbi.nlm.nih.gov/nuccore/NC_000932.1 ↩