Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma is a tumor made of cells from connective tissue. Mast cell sarcoma is an extremely rare tumor. The largest analysis to date comprises 34 cases. Prognosis is extremely poor. People with a mast cell sarcoma have no skin lesions, and pathology examination of the tumor shows it to be very malignant with an aggressive growth pattern. Mast cell sarcoma should not be confused with extracutaneous mastocytoma, a rare benign mast cell tumor without destructive growth. In the cases observed, mast cell sarcoma terminated quickly as mast cell leukemia; one of the most aggressive human cancers.
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References
Chott A, Guenther P, Huebner A, Selzer E, Parwaresch R, Horny H, Valent P (2003). "Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma". Am J Surg Pathol. 27 (7): 1013–9. doi:10.1097/00000478-200307000-00019. PMID 12826896. S2CID 46710032. /wiki/Doi_(identifier) ↩
Matsumoto, Nana P.; Yuan, Ji; Wang, Jun; Shen, Qi; Chen, Xueyan; Kim, Young; Zuppan, Craig W.; Chang, Chung-Che; Cui, Wei; Chen, Dong; Shi, Min; Gisriel, Savanah D.; Chen, Mingyi; Xu, Mina L.; Pan, Zenggang (July 2022). "Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature". Modern Pathology. 35 (7): 865–874. doi:10.1038/s41379-022-01014-w. PMID 35105959. https://doi.org/10.1038%2Fs41379-022-01014-w ↩
Nancy Gould, "Diagnosis and Classification of Mastocytosis Archived 2004-10-27 at the Wayback Machine", The Mastocytosis Society. http://www.tmsforacure.org/research/consensus.shtml ↩
Ansell, Stephen M., ed. (2008). Rare Hematological Malignancies. doi:10.1007/978-0-387-73744-7. ISBN 978-0-387-73743-0.[page needed] 978-0-387-73743-0 ↩