Replication timing quantitative trait loci

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Loci linked to replication timing

Replication timing quantitative trait loci (or rtQTL) are genetic variations that lead to differential use of replication origins, exhibiting allele-specific effects on replication timing. Originally, 16 rtQTL were identified in an analysis of human genomes.

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References

Koren, Amnon; Polak Paz; Nemesh James; Michaelson Jacob J; Sebat Jonathan; Sunyaev Shamil R; McCarroll Steven A (Dec 2012). "Differential relationship of DNA replication timing to different forms of human mutation and variation". Am. J. Hum. Genet. 91 (6). United States: 1033–40. doi:10.1016/j.ajhg.2012.10.018. PMC 3516607. PMID 23176822. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516607 ↩
Koren, A.; Handsaker, R. E.; Kamitaki, N.; Karlić, R.; Ghosh, S.; Polak, P.; Eggan, K.; McCarroll, S. A. (2014). "Genetic variation in human DNA replication timing". Cell. 159 (5): 1015–1026. doi:10.1016/j.cell.2014.10.025. PMC 4359889. PMID 25416942. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359889 ↩