SPNS2 - Reference.org

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SPNS2

Protein-coding gene in the species Homo sapiens

Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene.

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Model organisms

The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular development, and human SPNS2 can transport S1P analogues, including the immunomodulating drug FTY720-P.² ³

References

"Spinster homolog 2 (Drosophila)". Retrieved 2011-12-04. https://www.ncbi.nlm.nih.gov/gene/124976 ↩
Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (January 2009). "The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors". Science. 323 (5913): 524–7. Bibcode:2009Sci...323..524K. doi:10.1126/science.1167449. PMID 19074308. S2CID 44826764. https://doi.org/10.1126%2Fscience.1167449 ↩
Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T (January 2011). "The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720". The Journal of Biological Chemistry. 286 (3): 1758–66. doi:10.1074/jbc.M110.171116. PMC 3023470. PMID 21084291. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023470 ↩