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Setastine
Chemical compound

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.

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Pharmacology

Pharmacodynamics

Setastine acts as a highly selective H1 receptor antagonist.3 It has no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics

Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.4

See also

References

  1. Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica. 39 (1): 22–24. PMID 1677500. /wiki/PMID_(identifier) ↩

  2. Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica. 37 (4): 202–204. PMID 2576575. /wiki/PMID_(identifier) ↩

  3. Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–1345. PMID 1982751. /wiki/PMID_(identifier) ↩

  4. Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–1345. PMID 1982751. /wiki/PMID_(identifier) ↩