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TFCP2
Protein-coding gene in the species Homo sapiens

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcinoma. LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.

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Interactions

TFCP2 has been shown to interact with APBB111 and RNF2.12

Further reading

References

  1. Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi:10.1016/S0021-9258(19)78176-9. PMID 8157699. https://doi.org/10.1016%2FS0021-9258%2819%2978176-9 ↩

  2. "Entrez Gene: TFCP2 transcription factor CP2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7024 ↩

  3. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722317 ↩

  4. Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889542 ↩

  5. Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270996 ↩

  6. Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889542 ↩

  7. Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC 3365805. PMID 22679558. http://www.ajcr.us/files/ajcr0000110.pdf ↩

  8. Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889542 ↩

  9. Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC 3365805. PMID 22679558. http://www.ajcr.us/files/ajcr0000110.pdf ↩

  10. Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311344 ↩

  11. Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356. https://doi.org/10.1074%2Fjbc.273.32.20128 ↩

  12. Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC135618 ↩