Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.
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References
Getzler NA, Ereaux LP (March 1959). "Evaluation of thenalidine tratrate (sandostene) in dermatological disorders". Canadian Medical Association Journal. 80 (6): 445–8. PMC 1830689. PMID 13629433. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1830689 ↩
"Thenalidine". DrugBank. http://www.drugbank.ca/drugs/DB04826 ↩