Cefteram (INN) is a third-generation cephalosporin antibiotic.
Synthesis
The reaction of 7-aminocephalosporanic acid (1) with the methyl-substituted tetrazole (2) gives the intermediate (3). Protection with diazodiphenylmethane (4) produces (5). Amide formation with the thiazole carboxylic acid (6) gives (7), which is deprotected with trifluoroacetic acid to yield cefteram.23
References
Yamaguchi K, Ohno A, Takahashi S, Hayashi M, Yamanaka K, Hirakata Y, Mitsuyama J (January 1998). "[In vitro antibacterial activities of cefteram and other beta-lactam agents against recent clinical isolates]". The Japanese Journal of Antibiotics. 51 (1): 11–25. PMID 9557273. /wiki/PMID_(identifier) ↩
"Cefteram". chemdrug.com. Retrieved 2024-07-03. https://www.chemdrug.com/article/8/3284/16419968.html ↩
US patent 4489072, Hiroshi Sadaki, et al., issued 1984-12-18, assigned to Toyama Chemical Co Ltd https://worldwide.espacenet.com/textdoc?DB=EPODOC&IDX=US4489072 ↩