Marburg virus

<h2 id="history">History</h2>
<h3>Discovery</h3>
See also: <a href="/facts/1967_Marburg_virus_outbreak_in_West_Germany/G5FNsxJU">1967 Marburg virus outbreak</a>
Marburg virus was first described in 1967.<a class="footnote-ref" id="fnref:10" href="#fn:10">10</a> It was discovered that year during a set of outbreaks of Marburg virus disease in the German cities of <a href="/facts/Marburg/XSAjT1NP">Marburg</a> and <a href="/facts/Frankfurt/Pw4Xj9A4">Frankfurt</a> and the Yugoslav capital <a href="/facts/Belgrade/Xeaz5zIy">Belgrade</a>. Laboratory workers were exposed to tissues of infected <a href="/facts/Grivet/aPxT0Sxw">grivet monkeys</a> (the African green monkey, Chlorocebus aethiops) at the Behringwerke [de], a major industrial plant in Marburg which was then part of <a href="/facts/Hoechst_AG/jC4ydehg">Hoechst</a>, and later part of <a href="/facts/CSL_Behring/u982Wm6k">CSL Behring</a>. During the outbreaks, thirty-one people became infected and seven of them died.<a class="footnote-ref" id="fnref:11" href="#fn:11">11</a>
<h3>Nomenclature</h3>
The virus is one of two members of the species <a href="/facts/Marburgvirus/d2jVah0o">Marburgvirus</a>, which is included in the genus Marburgvirus, family <a href="/facts/Filoviridae/45SAAooF">Filoviridae</a>, and order <a href="/facts/Mononegavirales/nxfeEBrg">Mononegavirales</a>. The name Marburgvirus is derived from <a href="/facts/Marburg/XSAjT1NP">Marburg</a> (the city in <a href="/facts/Hesse/kEmEjUK9">Hesse</a>, Germany, where the virus was first discovered) and the <a href="/facts/Taxonomy_(biology)/Qkg8wuyw">taxonomic</a> suffix virus.<a class="footnote-ref" id="fnref:12" href="#fn:12">12</a>
Marburgvirus was first introduced under this name in 1967.<a class="footnote-ref" id="fnref:13" href="#fn:13">13</a> The virus name was changed to Lake Victoria marburgvirus in 2005, confusingly making the only difference in distinguishing between a Marburgvirus organism and its species as a whole italicization, as in Lake Victoria marburgvirus.<a class="footnote-ref" id="fnref:14" href="#fn:14">14</a><a class="footnote-ref" id="fnref:15" href="#fn:15">15</a><a class="footnote-ref" id="fnref:16" href="#fn:16">16</a> Still, most scientific articles continued to use the name Marburgvirus. Consequently, in 2010, the name Marburgvirus was reinstated and the species name changed.<a class="footnote-ref" id="fnref:17" href="#fn:17">17</a>

<h2 id="virology">Virology</h2>
<h3>Genome</h3>

Like all <a href="/facts/Mononegavirales/nxfeEBrg">mononegaviruses</a>, marburg virions contain non-infectious, linear nonsegmented, single-stranded <a href="/facts/RNA/HxPeNfNj">RNA</a> <a href="/facts/Genome/31Sm08JT">genomes</a> of negative polarity that possess inverse-complementary 3' and 5' termini, do not possess a <a href="/facts/5%2527_cap/cWUeEBJ6">5' cap</a>, are not <a href="/facts/Polyadenylation/ILnXUBKP">polyadenylated</a>, and are not <a href="/facts/Covalent_bond/EzMLf3Pz">covalently</a> linked to a <a href="/facts/Protein/Jxmagu3E">protein</a>.<a class="footnote-ref" id="fnref:18" href="#fn:18">18</a> Marburgvirus genomes are approximately 19 <a href="/facts/Base_pair/xmPpPQ9W">kbp</a> long and contain seven <a href="/facts/Gene/e1swwPY6">genes</a> in the order <a href="/facts/Three_prime_untranslated_region/wB0oYfKd">3'-UTR</a>-NP-VP35-VP40-GP-VP30-VP24-L-<a href="/facts/Five_prime_untranslated_region/xv930kS8">5'-UTR</a>.<a class="footnote-ref" id="fnref:19" href="#fn:19">19</a>

<h3>Structure</h3>

Like all <a href="/facts/Filoviridae/45SAAooF">filoviruses</a>, marburgvirions are filamentous particles that may appear in the shape of a shepherd's crook or in the shape of a "U" or a "6", and they may be coiled, toroid, or branched.<a class="footnote-ref" id="fnref:20" href="#fn:20">20</a> Marburgvirions are generally 80 nm in <a href="/facts/Width/EwFyAqGH">width</a>, but vary somewhat in length. In general, the median particle length of marburgviruses ranges from 795 to 828 nm (in contrast to <a href="/facts/Ebolavirus/VaToHQAD">ebolavirions</a>, whose median particle length was measured to be 974–1,086 nm), but particles as long as 14,000 nm have been detected in tissue culture.<a class="footnote-ref" id="fnref:21" href="#fn:21">21</a>
Marburgvirions consist of seven structural proteins. At the center is the <a href="/facts/Helix/BqC4AKwL">helical</a> <a href="/facts/Ribonucleoprotein/S07sU6hq">ribonucleocapsid</a>, which consists of the genomic RNA wrapped around a <a href="/facts/Polymer/eF32E50K">polymer</a> of <a href="/facts/Nucleoprotein/S07sU6hq">nucleoproteins</a> (NP). Associated with the ribonucleoprotein is the <a href="/facts/RNA-dependent_RNA_polymerase/UgPn4rjz">RNA-dependent RNA polymerase</a> (L) with the polymerase cofactor (VP35) and a transcription activator (VP30). The ribonucleoprotein is embedded in a matrix, formed by the major (VP40) and minor (VP24) matrix proteins. These particles are surrounded by a <a href="/facts/Lipid_bilayer/CQKQ9l3g">lipid membrane</a> derived from the host cell membrane. The membrane anchors a glycoprotein (GP1,2) that projects 7 to 10 nm spikes away from its surface. While nearly identical to ebolavirions in structure, marburgvirions are <a href="/facts/Antigen/9JlAernG">antigenically</a> distinct.<a class="footnote-ref" id="fnref:22" href="#fn:22">22</a>

<h3>Entry</h3>
<a href="/facts/NPC1/u3rh1RNx">Niemann–Pick C1</a> (NPC1) cholesterol transporter protein appears to be essential for infection with both <a href="/facts/Ebola_virus/BneCtC2m">Ebola</a> and Marburg virus. Two independent studies reported in the same issue of <a href="/facts/Nature_(journal)/XmlJXkFx">Nature</a> showed that <a href="/facts/Ebola_virus/BneCtC2m">Ebola virus</a> cell entry and replication requires NPC1.<a class="footnote-ref" id="fnref:23" href="#fn:23">23</a><a class="footnote-ref" id="fnref:24" href="#fn:24">24</a> When cells from patients lacking NPC1 were exposed to Ebola virus in the laboratory, the cells survived and appeared immune to the <a href="/facts/Virus/mf88Bcbl">virus</a>, further indicating that Ebola relies on NPC1 to enter cells. This might imply that genetic mutations in the NPC1 gene in humans could make some people resistant to one of the deadliest known viruses affecting humans. The same studies described similar results with Marburg virus, showing that it also needs NPC1 to enter cells.<a class="footnote-ref" id="fnref:25" href="#fn:25">25</a><a class="footnote-ref" id="fnref:26" href="#fn:26">26</a> Furthermore, NPC1 was shown to be critical to <a href="/facts/Filovirus/45SAAooF">filovirus</a> entry because it mediates infection by binding directly to the <a href="/facts/Viral_envelope/5P4eqVHn">viral envelope</a> glycoprotein<a class="footnote-ref" id="fnref:27" href="#fn:27">27</a> and that the second lysosomal domain of NPC1 mediates this binding.<a class="footnote-ref" id="fnref:28" href="#fn:28">28</a>
In one of the original studies, a <a href="/facts/Small_molecule/kbwq3VBn">small molecule</a> was shown to inhibit Ebola virus infection by preventing the virus glycoprotein from binding to NPC1.<a class="footnote-ref" id="fnref:29" href="#fn:29">29</a><a class="footnote-ref" id="fnref:30" href="#fn:30">30</a> In the other study, mice that were heterozygous for NPC1 were shown to be protected from lethal challenge with mouse-adapted Ebola virus.<a class="footnote-ref" id="fnref:31" href="#fn:31">31</a>

<h3>Replication</h3>

The Marburg virus <a href="/facts/Biological_life_cycle/1y28aNGG">life cycle</a> begins with virion attachment to specific cell-surface <a href="/facts/Receptor_(biochemistry)/tjTAC76a">receptors</a>, followed by <a href="/facts/Lipid_bilayer_fusion/8yh9sEnc">fusion</a> of the virion envelope with cellular membranes and the concomitant release of the virus <a href="/facts/Nucleocapsid/hm7V6Ewm">nucleocapsid</a> into the <a href="/facts/Cytosol/VyXgygWm">cytosol</a>.
The <a href="/facts/RNA-dependent_RNA_polymerase/UgPn4rjz">virus RdRp</a> partially uncoats the nucleocapsid and <a href="/facts/Transcription_(genetics)/bDgp9HDN">transcribes</a> the <a href="/facts/Genes/e1swwPY6">genes</a> into positive-stranded <a href="/facts/MRNA/oUL6qxQn">mRNAs</a>, which are then <a href="/facts/Translation_(biology)/JcPC1rth">translated</a> into structural and nonstructural <a href="/facts/Proteins/Jxmagu3E">proteins</a>. Marburgvirus L binds to a single <a href="/facts/Promoter_(biology)/YDYBzLfg">promoter</a> located at the 3' end of the genome. Transcription either terminates after a gene or continues to the next gene downstream. This means that genes close to the 3' end of the genome are transcribed in the greatest abundance, whereas those toward the 5' end are least likely to be transcribed. The gene order is therefore a simple but effective form of transcriptional regulation.<a class="footnote-ref" id="fnref:32" href="#fn:32">32</a>
The most abundant protein produced is the <a href="/facts/Nucleoprotein/S07sU6hq">nucleoprotein</a>, whose <a href="/facts/Concentration/wqBmz5od">concentration</a> in the cell determines when L switches from gene transcription to genome replication. Replication results in full-length, positive-stranded antigenomes that are in turn transcribed into negative-stranded virus progeny genome copies. Newly synthesized structural proteins and genomes self-assemble and accumulate near the inside of the <a href="/facts/Cell_membrane/vAXSD0DT">cell membrane</a>. Virions <a href="/facts/Budding/TEB3zXxB">bud</a> off from the cell, gaining their envelopes from the cellular membrane they bud from. The mature progeny particles then infect other cells to repeat the cycle.<a class="footnote-ref" id="fnref:33" href="#fn:33">33</a>

<h2 id="ecology">Ecology</h2>

In 2009, the successful isolation of infectious MARV was reported from caught healthy <a href="/facts/Rousettus_aegyptiacus/CB2Lpu71">Egyptian fruit bats (Rousettus aegyptiacus)</a>.<a class="footnote-ref" id="fnref:34" href="#fn:34">34</a> This isolation, together with the isolation of infectious <a href="/facts/RAVV/46xchRtI">RAVV</a>,<a class="footnote-ref" id="fnref:35" href="#fn:35">35</a> strongly suggests that <a href="/facts/Old_World/jt02swyQ">Old World</a> fruit <a href="/facts/Bat/CJudzNt1">bats</a> are involved in the natural maintenance of marburgviruses. Further studies are necessary to establish whether <a href="/facts/Egyptian_fruit_bat/CB2Lpu71">Egyptian rousettes</a> are the actual hosts of MARV and RAVV or whether they get infected via contact with another animal and therefore serve only as intermediate hosts. In 2012 the first experimental infection study of Rousettus aegyptiacus with MARV provided further insight into the possible involvement of these bats in MARV ecology.<a class="footnote-ref" id="fnref:36" href="#fn:36">36</a>
Experimentally infected bats developed relatively low viremia lasting at least five days, but remained healthy and did not develop any notable gross pathology. The virus also replicated to high titers in major organs (liver and spleen), and organs that might possibly be involved in virus transmission (lung, intestine, reproductive organs, salivary gland, kidney, bladder, and mammary gland). The relatively long period of viremia noted in this experiment could possibly also facilitate mechanical transmission by blood sucking arthropods in addition to infection of susceptible vertebrate hosts by direct contact with infected blood.<a class="footnote-ref" id="fnref:37" href="#fn:37">37</a>

<h2 id="evolution">Evolution</h2>
The viral strains fall into two clades: Ravn virus and Marburg virus.<a class="footnote-ref" id="fnref:38" href="#fn:38">38</a> The Marburg strains can be divided into two: A and B. The A strains were isolated from <a href="/facts/Uganda/PabdegRm">Uganda</a> (five from 1967), <a href="/facts/Kenya/Y9Ko9pQu">Kenya</a> (1980) and <a href="/facts/Angola/PQrYRHMd">Angola</a> (2004–2005) while the B strains were from the <a href="/facts/Democratic_Republic_of_the_Congo/E2KmHDdv">Democratic Republic of the Congo</a> epidemic (1999–2000) and a group of Ugandan isolates isolated in 2007–2009.<a class="footnote-ref" id="fnref:39" href="#fn:39">39</a>
The mean evolutionary rate of the whole genome was 3.3 × 10−4 substitutions/site/year (credibility interval 2.0–4.8). The Marburg strains had a mean root time of the most recent common ancestor of 177.9 years ago (95% highest posterior density 87–284) suggesting an origin in the mid 19th century. In contrast, the Ravn strains origin dated back to a mean 33.8 years ago (the early 1980s). The most probable location of the Marburg virus ancestor was Uganda whereas that of the RAVV ancestor was Kenya.

<h2 id="human-disease">Human disease</h2>
Main article: <a href="/facts/Marburg_virus_disease/Yc62Gqre">Marburg virus disease</a>
MARV is one of two Marburg viruses that causes <a href="/facts/Marburg_virus_disease/Yc62Gqre">Marburg virus disease (MVD)</a> in humans (in the literature also often referred to as Marburg hemorrhagic fever, MHF). The other one is <a href="/facts/Ravn_virus/46xchRtI">Ravn virus</a> (RAVV). Both viruses fulfill the criteria for being a member of the species Marburg marburgvirus because their <a href="/facts/Genome/31Sm08JT">genomes</a> diverge from the prototype Marburg marburgvirus or the Marburg virus variant Musoke (MARV/Mus) by <10% at the <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a> level.<a class="footnote-ref" id="fnref:40" href="#fn:40">40</a>

<h3>Recorded outbreaks</h3>
<table><tbody><tr><th>Year</th><th>Geographic location</th><th>Virus</th><th>Human cases</th><th>Human deaths</th><th><a href="/facts/Case_fatality_rate/gcPYD2Nx">Case fatality rate</a></th><th>Notes</th></tr><tr><td>1967</td><td><a href="/facts/Marburg/XSAjT1NP">Marburg</a> and <a href="/facts/Frankfurt/Pw4Xj9A4">Frankfurt</a>, <a href="/facts/West_Germany/oCydk787">West Germany</a>, and <a href="/facts/Belgrade/Xeaz5zIy">Belgrade</a>, <a href="/facts/Socialist_Federal_Republic_of_Yugoslavia/PXRlHx9q">Socialist Federal Republic of Yugoslavia</a></td><td>MARV</td><td>31</td><td>7</td><td>23%</td><td>Laboratory leak<a class="footnote-ref" id="fnref:41" href="#fn:41">41</a><a class="footnote-ref" id="fnref:42" href="#fn:42">42</a><a class="footnote-ref" id="fnref:43" href="#fn:43">43</a><a class="footnote-ref" id="fnref:44" href="#fn:44">44</a><a class="footnote-ref" id="fnref:45" href="#fn:45">45</a><a class="footnote-ref" id="fnref:46" href="#fn:46">46</a><a class="footnote-ref" id="fnref:47" href="#fn:47">47</a><a class="footnote-ref" id="fnref:48" href="#fn:48">48</a><a class="footnote-ref" id="fnref:49" href="#fn:49">49</a>[excessive citations]</td></tr><tr><td>1975</td><td><a href="/facts/Rhodesia/JHQJpmdj">Rhodesia</a> and <a href="/facts/Johannesburg/DQd9T8FY">Johannesburg</a>, <a href="/facts/South_Africa/vvXQpLgq">South Africa</a></td><td>MARV</td><td>3</td><td>1</td><td>33%</td><td><a class="footnote-ref" id="fnref:50" href="#fn:50">50</a><a class="footnote-ref" id="fnref:51" href="#fn:51">51</a><a class="footnote-ref" id="fnref:52" href="#fn:52">52</a></td></tr><tr><td>1980</td><td><a href="/facts/Kenya/Y9Ko9pQu">Kenya</a></td><td>MARV</td><td>2</td><td>1</td><td>50%</td><td><a class="footnote-ref" id="fnref:53" href="#fn:53">53</a></td></tr><tr><td>1987</td><td><a href="/facts/Kenya/Y9Ko9pQu">Kenya</a></td><td>RAVV</td><td>1</td><td>1</td><td>100%</td><td><a class="footnote-ref" id="fnref:54" href="#fn:54">54</a><a class="footnote-ref" id="fnref:55" href="#fn:55">55</a></td></tr><tr><td>1988</td><td><a href="/facts/Koltsovo%2c_Novosibirsk_Oblast/rudAv4LQ">Koltsovo</a>, <a href="/facts/Soviet_Union/m7wWsPto">Soviet Union</a></td><td></td><td>1</td><td>1</td><td>100%</td><td>Laboratory accident<a class="footnote-ref" id="fnref:56" href="#fn:56">56</a></td></tr><tr><td>1990</td><td><a href="/facts/Koltsovo%2c_Novosibirsk_Oblast/rudAv4LQ">Koltsovo</a>, <a href="/facts/Soviet_Union/m7wWsPto">Soviet Union</a></td><td>MARV</td><td>1</td><td>1</td><td>100%</td><td>Laboratory accident<a class="footnote-ref" id="fnref:57" href="#fn:57">57</a></td></tr><tr><td>1998–2000</td><td><a href="/facts/Durba%2c_Democratic_Republic_of_the_Congo/BnlbEmHk">Durba</a> and <a href="/facts/Watsa/rVW9op8x">Watsa</a>, <a href="/facts/Democratic_Republic_of_the_Congo/E2KmHDdv">Democratic Republic of the Congo</a></td><td>MARV & RAVV</td><td>154</td><td>128</td><td>83%</td><td>Two different marburgviruses, MARV and Ravn virus (RAVV), cocirculated and caused disease. The number of cases and deaths due to MARV or RAVV infection have not been reported.<a class="footnote-ref" id="fnref:58" href="#fn:58">58</a><a class="footnote-ref" id="fnref:59" href="#fn:59">59</a><a class="footnote-ref" id="fnref:60" href="#fn:60">60</a></td></tr><tr><td>2004–2005</td><td><a href="/facts/Angola/PQrYRHMd">Angola</a></td><td>MARV</td><td>374</td><td>329</td><td>90%</td><td><a class="footnote-ref" id="fnref:61" href="#fn:61">61</a><a class="footnote-ref" id="fnref:62" href="#fn:62">62</a><a class="footnote-ref" id="fnref:63" href="#fn:63">63</a><a class="footnote-ref" id="fnref:64" href="#fn:64">64</a><a class="footnote-ref" id="fnref:65" href="#fn:65">65</a><a class="footnote-ref" id="fnref:66" href="#fn:66">66</a><a class="footnote-ref" id="fnref:67" href="#fn:67">67</a>[excessive citations]</td></tr><tr><td>2007</td><td><a href="/facts/Uganda/PabdegRm">Uganda</a></td><td>MARV & RAVV</td><td>4</td><td>1</td><td>25%</td><td><a class="footnote-ref" id="fnref:68" href="#fn:68">68</a><a class="footnote-ref" id="fnref:69" href="#fn:69">69</a></td></tr><tr><td>2008</td><td><a href="/facts/Uganda/PabdegRm">Uganda</a> and <a href="/facts/The_Netherlands/y8xn5stT">The Netherlands</a></td><td>MARV</td><td>1</td><td>1</td><td>100%</td><td><a class="footnote-ref" id="fnref:70" href="#fn:70">70</a></td></tr><tr><td>2012</td><td><a href="/facts/Uganda/PabdegRm">Uganda</a></td><td>MARV</td><td>18</td><td>9</td><td>50%</td><td><a class="footnote-ref" id="fnref:71" href="#fn:71">71</a></td></tr><tr><td>2014</td><td><a href="/facts/Uganda/PabdegRm">Uganda</a></td><td>MARV</td><td>1</td><td>1</td><td>100%</td><td><a class="footnote-ref" id="fnref:72" href="#fn:72">72</a><a class="footnote-ref" id="fnref:73" href="#fn:73">73</a></td></tr><tr><td>2017</td><td><a href="/facts/Uganda/PabdegRm">Uganda</a></td><td>MARV</td><td>3</td><td>3</td><td>100%</td><td><a class="footnote-ref" id="fnref:74" href="#fn:74">74</a></td></tr><tr><td>2021</td><td><a href="/facts/Guinea/MaBu4ysQ">Guinea</a></td><td>MARV</td><td>1</td><td>1</td><td>100%</td><td>The Guinean government detected the case from a sample of patients who died on August 2, 2021, in the southern prefecture of Gueckedou near the country's borders with Sierra Leone and Liberia.<a class="footnote-ref" id="fnref:75" href="#fn:75">75</a><a class="footnote-ref" id="fnref:76" href="#fn:76">76</a><a class="footnote-ref" id="fnref:77" href="#fn:77">77</a></td></tr><tr><td><a href="/facts/2022_Marburg_virus_disease_outbreak_in_Ghana/w2MGQMeW">2022</a></td><td><a href="/facts/Ghana/IkUw32Ya">Ghana</a></td><td>MARV</td><td>4</td><td>3</td><td>75%</td><td>Four cases have been reported so far with preparations for a possible outbreak being made. On 17 July 2022, two cases were confirmed by Ghana,<a class="footnote-ref" id="fnref:78" href="#fn:78">78</a> with two more being subsequently confirmed on 27 July 2022.<a class="footnote-ref" id="fnref:79" href="#fn:79">79</a>See <a href="/facts/2022_Marburg_virus_disease_outbreak_in_Ghana/w2MGQMeW">Ghana Marburg virus outbreak 2022</a>.<a class="footnote-ref" id="fnref:80" href="#fn:80">80</a></td></tr><tr><td>February 2023</td><td><a href="/facts/Equatorial_Guinea/ARkq2P4f">Equatorial Guinea</a></td><td></td><td>25</td><td>11</td><td>44%</td><td>See <a href="/facts/2023_Marburg_virus_disease_outbreak_in_Equatorial_Guinea/s88nKA1r">2023 Marburg virus disease outbreak in Equatorial Guinea</a>.<a class="footnote-ref" id="fnref:81" href="#fn:81">81</a><a class="footnote-ref" id="fnref:82" href="#fn:82">82</a></td></tr><tr><td>March 2023</td><td><a href="/facts/Tanzania/MJueJ7E4">Tanzania</a></td><td></td><td>9</td><td>6</td><td>67%</td><td>See <a href="/facts/2023_Marburg_virus_disease_outbreak_in_Tanzania/B6ykzXf1">2023 Marburg virus disease outbreak in Tanzania</a>.<a class="footnote-ref" id="fnref:83" href="#fn:83">83</a><a class="footnote-ref" id="fnref:84" href="#fn:84">84</a></td></tr><tr><td>2024</td><td><a href="/facts/Rwanda/UKR5UdKy">Rwanda</a></td><td></td><td>58</td><td>13</td><td>22%</td><td>See <a href="/facts/Rwanda_Marburg_virus_disease_outbreak/wosWPwoE">Rwanda Marburg virus disease outbreak</a>.<a class="footnote-ref" id="fnref:85" href="#fn:85">85</a></td></tr><tr><td>2025</td><td><a href="/facts/Tanzania/MJueJ7E4">Tanzania</a></td><td></td><td>1</td><td>8 (suspected)</td><td></td><td>One case confirmed,<a class="footnote-ref" id="fnref:86" href="#fn:86">86</a> 24 suspected cases tested negative, 8 suspected cases no cause given (2025-01-21)<a class="footnote-ref" id="fnref:87" href="#fn:87">87</a></td></tr></tbody></table>
<h2 id="prevention">Prevention</h2>
<h3>Infection prevention and control</h3>

Main article: <a href="/facts/Prevention_of_viral_hemorrhagic_fever/tBgoxtcP">Prevention of viral hemorrhagic fever</a>
As with many similar virusses, viral transmission can be reduced by taking suitable <a href="/facts/Infection_prevention_and_control/BCsfKPUl">infection prevention and control</a> measures, such as cleaning, isolation, protective clothing, safe waste disposal, and safe funeral practices for those killed by the disease.

<h3>Vaccination</h3>
Main article: <a href="/facts/Marburg_vaccine/5F8gN1FY">Marburg vaccine</a>
The first clinical study testing the efficacy of a Marburg virus vaccine was conducted in 2014. The study tested a DNA vaccine and concluded that individuals inoculated with the vaccine exhibited some level of antibodies. However, these vaccines were not expected to provide definitive immunity.<a class="footnote-ref" id="fnref:88" href="#fn:88">88</a> Several animal models have shown to be effective in the research of Marburg virus, such as hamsters, mice, and non-human primates (NHPs). Mice are useful in the initial phases of vaccine development as they are ample models for mammalian disease, but their immune systems are still different enough from humans to warrant trials with other mammals.<a class="footnote-ref" id="fnref:89" href="#fn:89">89</a> Of these models, the infection in macaques seems to be the most similar to the effects in humans.<a class="footnote-ref" id="fnref:90" href="#fn:90">90</a> A variety of other vaccines have been considered. Virus replicon particles (VRPs) were shown to be effective in guinea pigs, but lost efficacy once tested on NHPs. Additionally, an inactivated virus vaccine proved ineffective. DNA vaccines showed some efficacy in NHPs, but all inoculated individuals showed signs of infection.<a class="footnote-ref" id="fnref:91" href="#fn:91">91</a>
Because Marburg virus and Ebola virus belong to the same family, Filoviridae, some scientists have attempted to create a single-injection vaccine for both viruses. This would both make the vaccine more practical and lower the cost for developing countries.<a class="footnote-ref" id="fnref:92" href="#fn:92">92</a> Using a single-injection vaccine has shown to not cause any adverse reactogenicity, which the possible immune response to vaccination, in comparison to two separate vaccinations.<a class="footnote-ref" id="fnref:93" href="#fn:93">93</a>
There is a candidate vaccine against the Marburg virus called rVSV-MARV. It was <a href="/facts/RVSV-ZEBOV_vaccine/tI0R3REo">developed alongside vaccines for closely-related Ebolaviruses by the Canadian government in the early 2000s</a>, twenty years before the outbreak. Production and testing of rVSV-MARV is blocked by legal monopolies held by the <a href="/facts/Merck_Group/5wXLtNQF">Merck Group</a>. Merck acquired rights to all the closely-related candidate vaccines in 2014, but declined to work on most of them, including the Marburg vaccine, for economic reasons. While Merck returned the rights to the abandoned vaccines to the Public Health Agency of Canada, the vital rVSV vaccine production techniques which Merck had gained (while bringing the closely-related <a href="/facts/RVSV-ZEBOV_vaccine/tI0R3REo">rVSV-ZEBOV vaccine</a> into commercial use in 2019, with <a href="/facts/GAVI/MIeAFEHv">GAVI</a> funding) remain Merck's, and cannot be used by anyone else wishing to develop a rVSV vaccine.<a class="footnote-ref" id="fnref:94" href="#fn:94">94</a><a class="footnote-ref" id="fnref:95" href="#fn:95">95</a><a class="footnote-ref" id="fnref:96" href="#fn:96">96</a><a class="footnote-ref" id="fnref:97" href="#fn:97">97</a>
As of June 23, 2022, researchers working with the <a href="/facts/Public_Health_Agency_of_Canada/77oerrQC">Public Health Agency of Canada</a> conducted a study which showed promising results of a recombinant vesicular stomatitis virus (rVSV) vaccine in guinea pigs, entitled PHV01. According to the study, inoculation with the vaccine approximately one month prior to infection with the virus provided a high level of protection.<a class="footnote-ref" id="fnref:98" href="#fn:98">98</a>
Even though there is much experimental research on Marburg virus, there is still no prominent vaccine. Human vaccination trials are either ultimately unsuccessful or are missing data specifically regarding Marburg virus.<a class="footnote-ref" id="fnref:99" href="#fn:99">99</a> Due to the cost needed to handle Marburg virus at qualified facilities, the relatively few number of fatalities, and lack of commercial interest, the possibility of a vaccine has simply not come to fruition<a class="footnote-ref" id="fnref:100" href="#fn:100">100</a> (see also <a href="/facts/Economics_of_vaccines/WUqzLeqY">economics of vaccines</a>).

<h2 id="biological-weapon">Biological weapon</h2>
The <a href="/facts/Soviet_Union/m7wWsPto">Soviet Union</a> had an extensive offensive and defensive <a href="/facts/Soviet_biological_weapons_program/dWHkSI7t">biological weapons</a> program that included MARV.<a class="footnote-ref" id="fnref:101" href="#fn:101">101</a> At least three Soviet research institutes had MARV research programs during the <a href="/facts/Cold_War/spJdJQ3q">Cold War</a>: The Virology Center of the <a href="/facts/Scientific_Research_Institute_of_Medicine_of_the_Ministry_of_Defense_in_Zagorsk/yzresR1T">Scientific Research Institute for Microbiology in Zagorsk</a> (today <a href="/facts/Sergiev_Posad/T2axHNx5">Sergiev Posad</a>), the Scientific-Production Association "Vektor" (today the <a href="/facts/State_Research_Center_of_Virology_and_Biotechnology_VECTOR/6aHNR1jl">State Research Center of Virology and Biotechnology "Vektor"</a>) in <a href="/facts/Koltsovo%2c_Novosibirsk_Oblast/rudAv4LQ">Koltsovo</a>, and the Irkutsk Scientific-Research Anti-Plague Institute of Siberia and the Far East in <a href="/facts/Irkutsk/tWMSLMNt">Irkutsk</a>.<a class="footnote-ref" id="fnref:102" href="#fn:102">102</a>
As most performed research was highly <a href="/facts/Classified_information/og7wn3tD">classified</a>, it remains unclear how successful the MARV program was. However, Soviet <a href="/facts/Defection/Up49mrVc">defector</a> <a href="/facts/Ken_Alibek/xYI7akmC">Ken Alibek</a> claimed that a weapon filled with MARV was tested at the <a href="/facts/Stepnagorsk_Scientific_and_Technical_Institute_for_Microbiology/765IBpge">Stepnogorsk Scientific Experimental and Production Base</a> in <a href="/facts/Stepnogorsk/FLtVzn53">Stepnogorsk</a>, <a href="/facts/Kazakh_Soviet_Socialist_Republic/qnq5kj2M">Kazakh Soviet Socialist Republic</a> (today <a href="/facts/Kazakhstan/Vfs8NI6e">Kazakhstan</a>),<a class="footnote-ref" id="fnref:103" href="#fn:103">103</a> suggesting that the development of a MARV biological weapon had reached advanced stages. Independent confirmation for this claim is lacking. At least one laboratory accident with MARV, resulting in the death of Koltsovo researcher Nikolai Ustinov, occurred during the Cold War in the Soviet Union and was first described in detail by Alibek.<a class="footnote-ref" id="fnref:104" href="#fn:104">104</a>
MARV is a <a href="/facts/Select_agent/8zR6LUkv">select agent</a> under US law.<a class="footnote-ref" id="fnref:105" href="#fn:105">105</a>

<h2 id="further-reading">Further reading</h2>

<ul><li>Klenk HD (1999). <a href="https://books.google.com/books?id=2ltWAAAAYAAJ">Marburg and Ebola Viruses</a>. Current Topics in Microbiology and Immunology. Vol. 235. Berlin, Germany: Springer-Verlag. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-3-540-64729-4.</li>
<li>Klenk HD, Feldmann H (2004). Ebola and Marburg Viruses: Molecular and Cellular Biology. Wymondham, Norfolk, UK: Horizon Bioscience. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-1-904933-49-6.</li>
<li>Kuhn JH (2008). <a href="https://books.google.com/books?id=ArZtuAEACAAJ">Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies</a>. Archives of Virology Supplement. Vol. 20. Vienna, Austria: Springer. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-3-211-20670-6.</li>
<li>Martini GA, Siegert R (1971). <a href="https://books.google.com/books?id=SoFrAAAAMAAJ">Marburg Virus Disease</a>. Berlin, Germany: Springer-Verlag. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-387-05199-4.</li>
<li>Ryabchikova EI, Price BB (2004). <a href="https://books.google.com/books?id=3PhqAAAAMAAJ">Ebola and Marburg Viruses: A View of Infection Using Electron Microscopy</a>. Columbus, Ohio, US: Battelle Press. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-1-57477-131-2.</li></ul>

<h2 id="external-links">External links</h2>

Wikimedia Commons has media related to Marburgvirus.

<ul><li><a href="https://ictv.global/">International Committee on Taxonomy of Viruses (ICTV)</a></li>
<li><a href="http://www.filovir.com">FILOVIR—scientific resources for research on filoviruses</a> <a href="https://web.archive.org/web/20200730224033/http://www.filovir.com/">Archived</a> 2020-07-30 at the <a href="/facts/Wayback_Machine/nmQ3a6JC">Wayback Machine</a></li></ul>

<h2 id="references">References</h2>

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</ol>

Marburg virus open-in-new

Marburg virus