Meningococcal vaccine

<h2 id="types">Types</h2>
<a href="/facts/Neisseria_meningitidis/u4SqwHuc">Neisseria meningitidis</a> has 13 clinically significant <a href="/facts/Serotype/fUllA0xY">serogroups</a>, classified according to the antigenic structure of their polysaccharide capsule.[medical citation needed] Six serogroups, A, B, C, Y, W-135, and X, are responsible for virtually all cases in humans. Serogroup B is a major cause of meningococcal disease in younger children and adolescents.[medical citation needed]

<h3>Pentavalent (serogroups A, B, C, W, and Y)</h3>
There are two quadrivalent vaccines available in the United States targeting serogroups A, B, C, W, and Y:

<ul><li>Penbraya was approved for use in the United States in October 2023.<a class="footnote-ref" id="fnref:22" href="#fn:22">22</a> It combines the vaccines Trumenba<a class="footnote-ref" id="fnref:23" href="#fn:23">23</a> and Nimenrix.<a class="footnote-ref" id="fnref:24" href="#fn:24">24</a> It is approved for use in individuals 10 through 25 years of age.<a class="footnote-ref" id="fnref:25" href="#fn:25">25</a></li></ul>
<ul><li>Penmenvy was approved for use in the United States in February 2025.<a class="footnote-ref" id="fnref:26" href="#fn:26">26</a><a class="footnote-ref" id="fnref:27" href="#fn:27">27</a><a class="footnote-ref" id="fnref:28" href="#fn:28">28</a><a class="footnote-ref" id="fnref:29" href="#fn:29">29</a> Penmenvy is approved for use in people aged 10 through 25 years of age.<a class="footnote-ref" id="fnref:30" href="#fn:30">30</a><a class="footnote-ref" id="fnref:31" href="#fn:31">31</a></li></ul>
<h3>Quadrivalent (serogroups A, C, W-135, and Y)</h3>
There are three quadrivalent vaccines available in the United States targeting serogroups A, C, W-135, and Y:

<ul><li>three <a href="/facts/Conjugate_vaccine/DwqFnI4L">conjugate vaccines</a> (MCV-4), Menactra,<a class="footnote-ref" id="fnref:32" href="#fn:32">32</a> Menveo,<a class="footnote-ref" id="fnref:33" href="#fn:33">33</a> and Menquadfi.<a class="footnote-ref" id="fnref:34" href="#fn:34">34</a> The pure polysaccharide vaccine Menomune, MPSV4, was discontinued in the United States in 2017.<a class="footnote-ref" id="fnref:35" href="#fn:35">35</a></li></ul>
Menveo and Menquadfi are approved for medical use in the European Union.<a class="footnote-ref" id="fnref:36" href="#fn:36">36</a><a class="footnote-ref" id="fnref:37" href="#fn:37">37</a><a class="footnote-ref" id="fnref:38" href="#fn:38">38</a>

<h4>Menactra and Menveo</h4>
The first meningococcal conjugate vaccine (MCV-4), Menactra, was licensed in the US in 2005, by <a href="/facts/Sanofi_Pasteur/fm2pqHee">Sanofi Pasteur</a>; Menveo was licensed in 2010, by <a href="/facts/Novartis/jDregKez">Novartis</a>. Both MCV-4 vaccines are approved by the <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) for people 2 through 55 years of age. Menactra received FDA approval for use in children as young as 9 months in April 2011,<a class="footnote-ref" id="fnref:39" href="#fn:39">39</a> while Menveo received FDA approval for use in children as young as two months in August 2013.<a class="footnote-ref" id="fnref:40" href="#fn:40">40</a> The <a href="/facts/Centers_for_Disease_Control_and_Prevention/NmoJNDV5">Centers for Disease Control and Prevention</a> (CDC) has not made recommendations for or against its use in children less than two years.<a class="footnote-ref" id="fnref:41" href="#fn:41">41</a> In November 2024, the <a href="/facts/European_Commission/Cc5JgbEI">European Commission</a> (EC) approved Menveo to protect individuals aged two years and older against <a href="/facts/Meningococcal_disease/uf5RYjFn">invasive meningococcal disease</a>.<a class="footnote-ref" id="fnref:42" href="#fn:42">42</a>

<h4>Menquadfi</h4>
Menquadfi, manufactured by <a href="/facts/Sanofi_Pasteur/fm2pqHee">Sanofi Pasteur</a>, was approved by the US <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> in April 2020, for use in individuals two years of age and older.<a class="footnote-ref" id="fnref:43" href="#fn:43">43</a>

<h4>Menomune</h4>
Meningococcal polysaccharide vaccine (MPSV-4), Menomune, has been available since the 1970s. It may be used if MCV-4 is not available, and is the only meningococcal vaccine licensed for people older than 55. Information about who should receive the meningococcal vaccine is available from the CDC.<a class="footnote-ref" id="fnref:44" href="#fn:44">44</a>

<h4>Nimenrix</h4>

Nimenrix (developed by GlaxoSmithKline and later acquired by <a href="/facts/Pfizer/1ADDanWs">Pfizer</a>), is a quadrivalent conjugate vaccine against serogroups A, C, W-135, and Y.<a class="footnote-ref" id="fnref:45" href="#fn:45">45</a> In April 2012 Nimenrix was approved as the first quadrivalent vaccine against invasive meningococcal disease to be administered as a single dose in those over the age of one year, by the European Medicines Agency.<a class="footnote-ref" id="fnref:46" href="#fn:46">46</a> In 2016, they approved the vaccine in infants six weeks of age and older, and it has been approved in other countries including Canada and Australia, among others.<a class="footnote-ref" id="fnref:47" href="#fn:47">47</a><a class="footnote-ref" id="fnref:48" href="#fn:48">48</a><a class="footnote-ref" id="fnref:49" href="#fn:49">49</a> It is not licensed in the United States.<a class="footnote-ref" id="fnref:50" href="#fn:50">50</a>

<h4>Mencevax</h4>
Mencevax (<a href="/facts/GlaxoSmithKline/NrnnxFNW">GlaxoSmithKline</a>) and <a href="/facts/NmVac4-A/C/Y/W-135/1C63J7aX">NmVac4-A/C/Y/W-135</a> (<a href="/facts/JN-International_Medical_Corporation/7kBTpnLC">JN-International Medical Corporation</a>) are used worldwide but have not been licensed in the United States.

<h4>Limitations</h4>
The duration of immunity mediated by Menomune (MPSV-4) is three years or less in children aged under five because it does not generate <a href="/facts/Memory_T_cell/xsavrTuS">memory T cells</a>.<a class="footnote-ref" id="fnref:51" href="#fn:51">51</a><a class="footnote-ref" id="fnref:52" href="#fn:52">52</a> Attempting to overcome this problem by repeated immunization results in a diminished, not increased, <a href="/facts/Antibody/MX8pdTdP">antibody</a> response, so boosters are not recommended with this vaccine.<a class="footnote-ref" id="fnref:53" href="#fn:53">53</a><a class="footnote-ref" id="fnref:54" href="#fn:54">54</a> As with all polysaccharide vaccines, Menomune does not produce <a href="/facts/Mucosal_immunity/YQzm2TEM">mucosal immunity</a>, so people can still become colonised with virulent strains of meningococcus, and no <a href="/facts/Herd_immunity/8y11dyAI">herd immunity</a> can develop.<a class="footnote-ref" id="fnref:55" href="#fn:55">55</a><a class="footnote-ref" id="fnref:56" href="#fn:56">56</a> For this reason, Menomune is suitable for travellers requiring short-term protection, but not for national public health prevention programs.
Menveo and Menactra contain the same antigens as Menomune, but the antigens are conjugated to a <a href="/facts/Diphtheria_toxin/ap7Ry3Qa">diphtheria toxoid</a> polysaccharide-protein complex, resulting in anticipated enhanced duration of protection, increased immunity with booster vaccinations, and effective herd immunity.<a class="footnote-ref" id="fnref:57" href="#fn:57">57</a>

<h4>Endurance</h4>
A study published in March 2006, comparing the two kinds of vaccines found that 76% of subjects still had passive protection three years after receiving MCV-4 (63% protective compared with controls), but only 49% had passive protection after receiving MPSV-4 (31% protective compared with controls).<a class="footnote-ref" id="fnref:58" href="#fn:58">58</a> As of 2010, there remains limited evidence that any of the current conjugate vaccines offer continued protection beyond three years; studies are ongoing to determine the actual duration of immunity, and the subsequent requirement of booster vaccinations. The CDC offers recommendations regarding who they feel should get booster vaccinations.<a class="footnote-ref" id="fnref:59" href="#fn:59">59</a><a class="footnote-ref" id="fnref:60" href="#fn:60">60</a>

<h3>Bivalent (serogroups C and Y)</h3>
In June 2012, the FDA approved a combination vaccine against two types of meningococcal disease and <a href="/facts/Hib_disease/wqIpoDI1">Hib disease</a> for infants and children 6 weeks to 18 months old. The vaccine, Menhibrix, prevents disease caused by <a href="/facts/Neisseria_meningitidis/u4SqwHuc">Neisseria meningitidis</a> <a href="/facts/Serotypes/fUllA0xY">serogroups</a> C and Y and <a href="/facts/Haemophilus_influenzae/wqIpoDI1">Haemophilus influenzae</a> type b. This was the first meningococcal vaccine that could be given to infants as young as six weeks old.<a class="footnote-ref" id="fnref:61" href="#fn:61">61</a> Menhibrix is <a href="/facts/Indicated/DLdGwxDY">indicated</a> for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b for children 6 weeks of age through 18 months of age.<a class="footnote-ref" id="fnref:62" href="#fn:62">62</a>

<h3>Serogroup A</h3>
A vaccine called <a href="/facts/MenAfriVac/5kFncXbR">MenAfriVac</a> has been developed through a program called the <a href="/facts/Meningitis_Vaccine_Project/APMl9Ftg">Meningitis Vaccine Project</a> and has the potential to prevent outbreaks of group A meningitis, which is common in sub-Saharan Africa.<a class="footnote-ref" id="fnref:63" href="#fn:63">63</a><a class="footnote-ref" id="fnref:64" href="#fn:64">64</a>

<h3>Serogroup B</h3>

Vaccines against serotype B meningococcal disease have proved difficult to produce, and require a different approach from vaccines against other serotypes. Whereas effective <a href="/facts/Polysaccharide/lqXq2cJU">polysaccharide</a> vaccines have been produced against types A, C, W-135, and Y, the capsular polysaccharide on the type B bacterium is too similar to <a href="/facts/Neural_cell_adhesion_molecule/AQAGclUp">human neural adhesion molecules</a> to be a useful target.<a class="footnote-ref" id="fnref:65" href="#fn:65">65</a>
Several "serogroup B" vaccines have been produced. Strictly speaking, these are not "serogroup B" vaccines, as they do not aim to produce antibodies to the group B antigen: it would be more accurate to describe them as serogroup-independent vaccines, as they employ different antigenic components of the organism; indeed, some of the antigens are common to different Neisseria species.[medical citation needed]
A vaccine for serogroup B was developed in Cuba in response to a large outbreak of meningitis B during the 1980s. This vaccine was based on artificially produced <a href="/facts/Bacterial_outer_membrane_vesicles/7tlfVmeh">outer membrane vesicles</a> of the bacterium. The VA-MENGOC-BC vaccine proved safe and effective in randomized double-blind studies,<a class="footnote-ref" id="fnref:66" href="#fn:66">66</a><a class="footnote-ref" id="fnref:67" href="#fn:67">67</a><a class="footnote-ref" id="fnref:68" href="#fn:68">68</a> but it was granted a licence only for research purposes in the United States<a class="footnote-ref" id="fnref:69" href="#fn:69">69</a> as political differences limited cooperation between the two countries.<a class="footnote-ref" id="fnref:70" href="#fn:70">70</a>
Due to a similarly high prevalence of B-serotype meningitis in Norway between 1974 and 1988, Norwegian health authorities developed a vaccine specifically designed for Norwegian children and adolescents. Clinical trials were discontinued after the vaccine was shown to cover only slightly more than 50% of all cases.<a class="footnote-ref" id="fnref:71" href="#fn:71">71</a> Furthermore, lawsuits for damages were filed against the State of Norway by persons affected by serious adverse reactions. Information that the health authorities obtained during the vaccine development was subsequently passed on to <a href="/facts/Chiron/yb6lqDEt">Chiron</a> (now GlaxoSmithKline), who developed a similar vaccine, <a href="/facts/MeNZB/VxmMr44C">MeNZB</a>, for New Zealand.<a class="footnote-ref" id="fnref:72" href="#fn:72">72</a>
A MenB vaccine was approved for use in Europe in January 2013. Following a positive recommendation from the European Union's <a href="/facts/Committee_for_Medicinal_Products_for_Human_Use/yCkJTISe">Committee for Medicinal Products for Human Use</a>, Bexsero, produced by <a href="/facts/Novartis/jDregKez">Novartis</a>, received a licence from the <a href="/facts/European_Commission/Cc5JgbEI">European Commission</a>.<a class="footnote-ref" id="fnref:73" href="#fn:73">73</a> However, deployment in individual EU member countries still depends on decisions by national governments. In July 2013, the United Kingdom's <a href="/facts/Joint_Committee_on_Vaccination_and_Immunisation/2zACoaSs">Joint Committee on Vaccination and Immunisation</a> (JCVI) issued an interim position statement recommending against the adoption of Bexsero as part of a routine meningococcal B immunisation program, on the grounds of cost-effectiveness.<a class="footnote-ref" id="fnref:74" href="#fn:74">74</a> This decision was reverted in favor of Bexsero vaccination in March 2014.<a class="footnote-ref" id="fnref:75" href="#fn:75">75</a> In March 2015 the UK government announced that they had reached agreement with <a href="/facts/GlaxoSmithKline/NrnnxFNW">GlaxoSmithKline</a> who had taken over Novartis's vaccines business, and that Bexsero would be introduced into the UK routine immunization schedule later in 2015.<a class="footnote-ref" id="fnref:76" href="#fn:76">76</a>
In November 2013, in response to an outbreak of B-serotype meningitis on the campus of <a href="/facts/Princeton_University/n3EPGHBM">Princeton University</a>, the acting head of the <a href="/facts/Centers_for_Disease_Control_and_Prevention/NmoJNDV5">Centers for Disease Control and Prevention</a> (CDC) meningitis and vaccine-preventable diseases branch told <a href="/facts/NBC_News/hWQ2wFfx">NBC News</a> that they had authorized emergency importation of Bexsero to stop the outbreak.<a class="footnote-ref" id="fnref:77" href="#fn:77">77</a> Bexsero was subsequently approved by the FDA in February 2015 for use in individuals 10 through 25 years of age.<a class="footnote-ref" id="fnref:78" href="#fn:78">78</a><a class="footnote-ref" id="fnref:79" href="#fn:79">79</a> In October 2014, Trumenba, a serogroup B vaccine produced by <a href="/facts/Pfizer/1ADDanWs">Pfizer</a>, was approved by the FDA for use in individuals 10 through 25 years of age.<a class="footnote-ref" id="fnref:80" href="#fn:80">80</a><a class="footnote-ref" id="fnref:81" href="#fn:81">81</a>

<h3>Serogroup X</h3>
The occurrence of serogroup X has been reported in North America, Europe, Australia, and West Africa.<a class="footnote-ref" id="fnref:82" href="#fn:82">82</a> There is no vaccine to protect against serogroup X N. meningitidis disease.<a class="footnote-ref" id="fnref:83" href="#fn:83">83</a>

<h2 id="side-effects">Side effects</h2>
Common side effects include pain and redness around the site of injection (up to 50% of recipients). A small percentage of people develop a mild fever. A small proportion of people develop a severe allergic reaction.<a class="footnote-ref" id="fnref:84" href="#fn:84">84</a> In 2016 Health Canada warned of an increased risk of anemia or <a href="/facts/Hemolysis/1WpVYHkP">hemolysis</a> in people treated with <a href="/facts/Eculizumab/4zPtDUQG">eculizumab</a> (Soliris). The highest risk was when individuals "received a dose of Soliris within 2 weeks after being vaccinated with Bexsero".<a class="footnote-ref" id="fnref:85" href="#fn:85">85</a>
Despite initial concerns about <a href="/facts/Guillain-Barr%C3%A9_syndrome/013kC53b">Guillain-Barré syndrome</a>, subsequent studies in 2012 have shown no increased risk of GBS after meningococcal conjugate vaccination.<a class="footnote-ref" id="fnref:86" href="#fn:86">86</a>

<h2 id="travel-requirements">Travel requirements</h2>

See also: <a href="/facts/Vaccination_requirements_for_international_travel/4KSgXry5">Vaccination requirements for international travel</a>
Travellers who wish to enter or leave certain countries or territories must be vaccinated against meningococcal meningitis, preferably 10–14 days before crossing the border, and be able to present a vaccination record/certificate at the border checks.<a class="footnote-ref" id="fnref:87" href="#fn:87">87</a>: 21–24  Countries with required meningococcal vaccination for travellers include <a href="/facts/The_Gambia/en5tl7Sz">The Gambia</a>, Indonesia, Lebanon, Libya, the Philippines and, most importantly and extensively, Saudi Arabia for Muslims visiting or working in <a href="/facts/Mecca/udqyuk0k">Mecca</a> during the <a href="/facts/Hajj/eDC5AalN">Hajj</a> or <a href="/facts/Umrah/xYoFxhDq">Umrah</a> pilgrimages.<a class="footnote-ref" id="fnref:88" href="#fn:88">88</a> For some countries in <a href="/facts/African_meningitis_belt/E932YGqu">African meningitis belt</a>, vaccinations prior to entry are not required, but highly recommended.<a class="footnote-ref" id="fnref:89" href="#fn:89">89</a>: 21–24 

<table><tbody><tr><th colspan="2">Meningococcal vaccination requirements for international travel<a class="footnote-ref" id="fnref:90" href="#fn:90">90</a></th></tr><tr><th>Country or territory</th><th>Details</th></tr><tr><td> <a href="/facts/The_Gambia/en5tl7Sz">The Gambia</a></td><td>All travellers must show proof of vaccination with the quadrivalent meningococcal vaccine (ACYW135) upon arrival.<a class="footnote-ref" id="fnref:91" href="#fn:91">91</a></td></tr><tr><td> <a href="/facts/Indonesia/vQnWU3IW">Indonesia</a></td><td>Travellers arriving from or departing to Saudi Arabia must show proof of vaccination with quadrivalent ACYW-135.<a class="footnote-ref" id="fnref:92" href="#fn:92">92</a></td></tr><tr><td> <a href="/facts/Lebanon/2dReTXyp">Lebanon</a></td><td>Proof of vaccination with quadrivalent ACYW-135 is required for travellers departing Lebanon and going to Hajj, Umrah, and to certain African countries.<a class="footnote-ref" id="fnref:93" href="#fn:93">93</a></td></tr><tr><td> <a href="/facts/Libya/HMPH8PWR">Libya</a></td><td>All travellers must show proof of vaccination with quadrivalent ACYW-135 upon arrival.<a class="footnote-ref" id="fnref:94" href="#fn:94">94</a></td></tr><tr><td> <a href="/facts/Philippines/ARpmxXQV">Philippines</a></td><td>Proof of vaccination with quadrivalent ACYW-135 is required for travellers going to Hajj and Umrah (in Saudi Arabia).<a class="footnote-ref" id="fnref:95" href="#fn:95">95</a></td></tr><tr><td> <a href="/facts/Saudi_Arabia/uyUpe1J2">Saudi Arabia</a></td><td><ul><li>Proof of vaccination is required for travellers two years of age and older who are Hajj or Umrah pilgrims and seasonal or pilgrim workers in Hajj and Umrah areas. Vaccination with quadrivalent ACYW135 (either polysaccharide or conjugate) must be issued not less than 10 days before arrival and not more than 3 years (polysaccharide vaccine) or 5 years (conjugate vaccine) before arrival. The immunisation certificate should clearly state if the traveller was vaccinated with the conjugate vaccine for the 5-year validity to apply.<a class="footnote-ref" id="fnref:96" href="#fn:96">96</a></li><li>Vaccination is also required for domestic pilgrims, residents of Mecca and Medina, and any persons participating in Hajj or Umrah or seasonal or pilgrimage work in Hajj and Umrah zones. At the discretion of the Ministry of Health, travellers may be administered prophylactic antibiotics upon arrival.<a class="footnote-ref" id="fnref:97" href="#fn:97">97</a></li></ul></td></tr></tbody></table>

<h2 id="further-reading">Further reading</h2>

<ul><li>Conterno LO, Silva Filho CR, Rüggeberg JU, Heath PT (2006). Conterno LO (ed.). "Conjugate vaccines for preventing meningococcal C meningitis and septicaemia". Cochrane Database Syst Rev. 3 (3): CD001834. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F14651858.CD001834.pub2">10.1002/14651858.CD001834.pub2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16855979">16855979</a>.</li>
<li>Patel M, Lee CK (2005). Patel M (ed.). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852230">"Polysaccharide vaccines for preventing serogroup A meningococcal meningitis"</a>. Cochrane Database Syst Rev (1): CD001093. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F14651858.CD001093.pub2">10.1002/14651858.CD001093.pub2</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852230">11852230</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15674874">15674874</a>.</li>
<li>Hall E, Wodi AP, Hamborsky J, Morelli V, Schillie S, eds. (2021). <a href="https://www.cdc.gov/vaccines/pubs/pinkbook/mening.html">"Chapter 14: Meningococcal Disease"</a>. <a href="https://www.cdc.gov/vaccines/pubs/pinkbook/index.html">Epidemiology and Prevention of Vaccine-Preventable Diseases</a> (14th ed.). Washington D.C.: U.S. <a href="/facts/Centers_for_Disease_Control_and_Prevention/NmoJNDV5">Centers for Disease Control and Prevention</a> (CDC). <a href="https://web.archive.org/web/20161230001534/https://www.cdc.gov/vaccines/pubs/pinkbook/index.html">Archived</a> from the original on 30 December 2016. Retrieved 17 February 2023.</li></ul>

<h2 id="external-links">External links</h2>
<ul><li><a href="https://www.cdc.gov/vaccines/hcp/current-vis/meningococcal-acwy.html">"Meningococcal ACWY Vaccine Information Statement"</a>. U.S. <a href="/facts/Centers_for_Disease_Control_and_Prevention/NmoJNDV5">Centers for Disease Control and Prevention</a> (CDC).</li>
<li><a href="https://www.cdc.gov/vaccines/hcp/current-vis/meningococcal-b.html">"Meningococcal B Vaccine Information Statement"</a>. U.S. <a href="/facts/Centers_for_Disease_Control_and_Prevention/NmoJNDV5">Centers for Disease Control and Prevention</a> (CDC).</li>
<li><a href="https://meshb.nlm.nih.gov/record/ui?name=Meningococcal+Vaccines">Meningococcal Vaccines</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1">World Health Organization (November 2011). "Meningococcal vaccines : WHO position paper, November 2011" (PDF). Wkly. Epidemiol. Rec. 86 (47): 521–540. hdl:10665/241846. PMID 22128384. Archived from the original (PDF) on 29 August 2021. Retrieved 20 December 2019. <a href="https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1" target="_blank">https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></li>
<li id="fn:2">World Health Organization (November 2011). "Meningococcal vaccines : WHO position paper, November 2011" (PDF). Wkly. Epidemiol. Rec. 86 (47): 521–540. hdl:10665/241846. PMID 22128384. Archived from the original (PDF) on 29 August 2021. Retrieved 20 December 2019. <a href="https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1" target="_blank">https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></li>
<li id="fn:3">"First vaccine approved by FDA to prevent serogroup B Meningococcal disease" (Press release). U.S. Food and Drug Administration (FDA). 29 October 2014. Archived from the original on 15 June 2019. Retrieved 19 October 2019. <a href="https://www.fda.gov/news-events/press-announcements/first-vaccine-approved-fda-prevent-serogroup-b-meningococcal-disease" target="_blank">https://www.fda.gov/news-events/press-announcements/first-vaccine-approved-fda-prevent-serogroup-b-meningococcal-disease</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></li>
<li id="fn:4">World Health Organization (November 2011). "Meningococcal vaccines : WHO position paper, November 2011" (PDF). Wkly. Epidemiol. Rec. 86 (47): 521–540. hdl:10665/241846. PMID 22128384. Archived from the original (PDF) on 29 August 2021. Retrieved 20 December 2019. <a href="https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1" target="_blank">https://web.archive.org/web/20210829150513/https://www.who.int/immunization/position_papers/MC_summary_14_Nov_2011.pdf?ua=1</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></li>
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</ol>

Meningococcal vaccine open-in-new

Meningococcal vaccine