By December 2004, Holmes had raised $6 million to fund the firm. By the end of 2010, Theranos had more than $92 million in venture capital. In July 2011, Holmes was introduced to former secretary of state George Shultz. After a two-hour meeting, he joined the Theranos board of directors. Holmes was recognized for forming "the most illustrious board in U.S. corporate history" over the next three years.
In July 2016, CMS banned Holmes from owning, operating, or directing a blood-testing service for a period of two years. Theranos appealed that decision to a U.S. Department of Health and Human Services appeals board. Shortly thereafter, Walgreens ended its relationship with Theranos and closed its in-store blood collection centers. The U.S. Food and Drug Administration (FDA) also ordered the company to cease use of its Capillary Tube Nanotainer device, one of its core inventions.
In 2017, the State of Arizona filed suit against Theranos, alleging that the company had sold 1.5 million blood tests to Arizonans while concealing or misrepresenting important facts about those tests. In April 2017, the company settled the lawsuit by agreeing to refund the cost of the tests to consumers, and to pay $225,000 in civil fines and attorney fees, for a total of $4.65 million. Other reported ongoing actions include an unspecified investigation by the U.S. Federal Bureau of Investigation (FBI) and two class action fraud lawsuits. Holmes denied any wrongdoing.
On May 16, 2017, approximately 99 percent of Theranos shareholders reached an agreement with the company to dismiss all litigation and potential litigation in exchange for shares of preferred stock. Holmes released a portion of her equity to offset any dilution of stock value to non-participating shareholders.
In March 2018, the SEC charged Holmes and Theranos's former president, Ramesh Balwani, with fraud by taking more than $700 million from investors while advertising a false product. The charges of fraud included the company's false claim that its technology was being used by the U.S. Department of Defense in combat situations. The company also lied when it claimed to have a $100-million revenue stream in 2014. That year, the company only made $100,000. On March 14, 2018, Holmes settled the lawsuit. The terms of Holmes's settlement included surrendering voting control of Theranos, returning 18.9 million shares to the company, a ban on holding an officer or director position in a public company for 10 years, and a $500,000 fine.
At its height in 2015, Theranos had more than 800 employees. It dismissed 340 people in October 2016 and an additional 155 in January 2017. In April 2018, Theranos filed a WARN Act notice with the State of California, announcing its plans to permanently lay off 105 employees, leaving it with fewer than two dozen employees. Most of the remaining employees were laid off in August 2018. On September 5, 2018, the company announced that it had begun the process of formally dissolving, with its remaining cash and assets to be distributed to its creditors.
On November 18, 2022, Davila sentenced Holmes to 11+1⁄4 years in federal prison and ordered her and Balwani jointly to pay $452 million in restitution to the victims of the fraud. He recommended she be incarcerated at Federal Prison Camp, Bryan, a minimum-security federal prison in Bryan, Texas. On May 17, 2023, Davila ruled that she must surrender to custody on May 30, after accepting that she needed time to arrange childcare for her two children. Holmes reported to prison on May 30. In July 2023, the Bureau of Prisons projected that Holmes would be released from prison in 2032, approximately two years early, in accordance with the Bureau's guidelines for good conduct time.
Theranos's board and investors included many influential figures. Holmes's first major investor was Tim Draper – Silicon Valley venture capitalist and father of Holmes's childhood friend Jesse Draper – who "cut Holmes a check" for $1 million upon hearing her initial pitch for the firm that would become Theranos. Theranos's pool of major investors expanded to include Rupert Murdoch, the Walton family, the DeVos family including Betsy DeVos, the Cox family of Cox Enterprises and Carlos Slim Helú. Each of these investors lost tens to hundreds of millions of dollars when Theranos folded.
Before the collapse of Theranos, Holmes received widespread acclaim. In 2015, she was appointed a member of the Harvard Medical School Board of Fellows and was named one of Time magazine's "Time 100 most influential people". Holmes received the Under 30 Doers Award from Forbes and was ranked number 73 in its 2015 list of "the world's most powerful women". She was also named Woman of the Year by Glamour and received an Honorary Doctor of Humane Letters from Pepperdine University.
Balwani divorced his wife in 2002 and became romantically involved with Holmes in 2003, about the same time Holmes dropped out of university. The couple moved into an apartment together in 2005. Although Balwani did not officially join Theranos until 2009, when he was given the title of chief operating officer, he was advising Holmes behind the scenes from the company's inception. Balwani left Theranos in 2016 in the wake of investigations. The circumstances of his departure are unclear; Holmes has stated that she fired him, but Balwani says that he left of his own accord.
On November 29, 2021, Holmes testified that she had been raped while she was a student at Stanford and that she sought solace from Balwani in the aftermath of the incident. She also said Balwani was very controlling during their romantic relationship, which lasted more than a decade, and at times he berated and sexually abused her. In her testimony, she stated he also wanted to "kill the person" she was and create a "new Elizabeth". However, she also testified that Balwani had not forced her to make the false statements to investors, business partners, journalists and company directors that had been described in the case. In court filings, Balwani has "categorically" denied abuse allegations, calling them "false and inflammatory."
Holmes first met William "Billy" Evans in early 2017. In early 2019, Holmes became engaged to Evans, a 27-year-old heir to Evans Hotels, a family-owned group of hotels in the San Diego area. In mid-2019, Holmes and Evans reportedly married in a private ceremony. Holmes and Evans have not directly confirmed whether the two are legally married, and several sources continue to refer to him as her "partner" rather than her husband. Holmes gave birth to a son in July 2021. In October 2022, weeks before her sentencing hearing, it was reported she was pregnant with a second child. Holmes was accused of conceiving a second child, according to a court filing from February 2023, as a strategy for delaying the start of her prison term. Holmes denied this, saying she wanted to grow her family and the child was conceived before she was indicted, which she did not anticipate. Prior to her incarceration, she lived in the Mortimer Fleishhacker House in Woodside, California with her partner.
The case of Holmes is said to have created a stigma for other female entrepreneurs, particularly in the sciences and health care industries, who are often compared to her. Writing in The New York Times, technology journalist Erin Griffith commented that "Holmes continues to loom large across the start-up world because of the audacity of her story, which has permeated popular culture", with female entrepreneurs reporting that "the frequent comparisons [to Holmes] are pernicious". Holmes has also been featured in a number of media works:
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