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TYRO3
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<h2 id="interactions">Interactions</h2> <p>TYRO3 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/GAS6/ng4BakeI">GAS6</a>,<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> and</li> <li><a href="/facts/PIK3R1/6TEzDV6r">PIK3R1</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994). <a href="https://doi.org/10.1016%2FS0021-9258%2817%2934118-2">"rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain"</a>. <i>J. Biol. Chem</i>. 269 (14): 10720–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2817%2934118-2">10.1016/S0021-9258(17)34118-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7511603">7511603</a>.</li> <li>Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". <i>Biochem. Biophys. Res. Commun</i>. 209 (2): 656–63. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.1995.1549">10.1006/bbrc.1995.1549</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7537495">7537495</a>.</li> <li>Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC, Crosier PS (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". <i>Growth Factors</i>. 11 (2): 137–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.3109%2F08977199409001055">10.3109/08977199409001055</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7857658">7857658</a>.</li> <li>Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". <i>Oncogene</i>. 9 (3): 699–705. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8108112">8108112</a>.</li> <li>Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". <i>Oncogene</i>. 9 (3): 975–9. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8108143">8108143</a>.</li> <li>Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA, Guida LC, Nicholls RD, Alitalo K (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". <i>Gene</i>. 134 (2): 289–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2893%2990109-G">10.1016/0378-1119(93)90109-G</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8262388">8262388</a>.</li> <li>Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996). <a href="https://doi.org/10.1074%2Fjbc.271.16.9785">"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl"</a>. <i>J. Biol. Chem</i>. 271 (16): 9785–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.16.9785">10.1074/jbc.271.16.9785</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8621659">8621659</a>.</li> <li>Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". <i>Exp. Hematol</i>. 24 (2): 318–23. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8641360">8641360</a>.</li> <li>Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (1997). <a href="https://doi.org/10.1074%2Fjbc.271.47.30022">"Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases"</a>. <i>J. Biol. Chem</i>. 271 (47): 30022–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.47.30022">10.1074/jbc.271.47.30022</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8939948">8939948</a>.</li> <li>Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T, Ohno K, Takashima S, Onodera K (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". <i>Biol. Cell</i>. 88 (1–2): 45–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0248-4900%2897%2986830-X">10.1016/S0248-4900(97)86830-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9175267">9175267</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:31494402">31494402</a>.</li> <li>Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". <i>Blood</i>. 95 (2): 633–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood.V95.2.633">10.1182/blood.V95.2.633</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10627473">10627473</a>.</li> <li>Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". <i>Transpl. Int</i>. 16 (9): 681–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs00147-003-0593-3">10.1007/s00147-003-0593-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12768229">12768229</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:13419387">13419387</a>.</li> <li>Heiring C, Dahlbäck B, Muller YA (2004). <a href="https://doi.org/10.1074%2Fjbc.M311750200">"Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family"</a>. <i>J. Biol. Chem</i>. 279 (8): 6952–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M311750200">10.1074/jbc.M311750200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14623883">14623883</a>.</li> <li>Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (2005). <a href="https://doi.org/10.1111%2Fj.1538-7836.2005.01186.x">"Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses"</a>. <i>J. Thromb. Haemost</i>. 3 (4): 733–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1538-7836.2005.01186.x">10.1111/j.1538-7836.2005.01186.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15733062">15733062</a>.</li> <li>Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". <i>Int. J. Biochem. Cell Biol</i>. 37 (11): 2344–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.biocel.2005.05.006">10.1016/j.biocel.2005.05.006</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15964779">15964779</a>.</li> <li>Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617303">"Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses"</a>. <i>J. Virol</i>. 80 (20): 10109–16. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FJVI.01157-06">10.1128/JVI.01157-06</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617303">1617303</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17005688">17005688</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (March 1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7301" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7301</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659. <a href="https://doi.org/10.1074%2Fjbc.271.16.9785" target="_blank">https://doi.org/10.1074%2Fjbc.271.16.9785</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948. <a href="https://doi.org/10.1074%2Fjbc.271.47.30022" target="_blank">https://doi.org/10.1074%2Fjbc.271.47.30022</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood. 95 (2): 633–8. doi:10.1182/blood.V95.2.633. PMID 10627473. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>