ATP synthase delta/OSCP subunit

ATP synthase delta subunit is a <a href="/facts/Protein_subunit/HhuET9UP">subunit</a> of <a href="/facts/Bacteria/wC8xSCsU">bacterial</a> and <a href="/facts/Chloroplast/fo8U3yTx">chloroplast</a> <a href="/facts/F-ATPase/gw2r7PUE">F-ATPase</a>/<a href="/facts/ATP_synthase/5NBMxsVX">synthase</a>. It is known as OSCP (<a href="/facts/Oligomycin/FbV6fUav">oligomycin</a> sensitivity conferral <a href="/facts/Protein/Jxmagu3E">protein</a>) in mitochondrial ATPase (note that in <a href="/facts/Mitochondria/ErHqrdJ1">mitochondria</a> there is a different delta subunit, <a href="/facts/ATP_synthase_delta%2fepsilon_subunit/ALusbghH">ATP synthase delta/epsilon subunit</a>).
The OSCP/delta subunit appears to be part of the <a href="/facts/Peripheral/3lEBPE14">peripheral</a> stalk that holds the F1 complex α3β3 catalytic core stationary against the <a href="/facts/Torque/KcrcvNtV">torque</a> of the rotating central stalk, and links subunit A of the FO complex with the F1 complex. In mitochondria, the peripheral stalk consists of OSCP, as well as FO components F6, B and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions: delta and two copies of FO component B (bacteria), or delta and FO components B and B' (chloroplasts).
F-ATPases lacking this subunit generally transport sodium instead of protons. They are proposed to be called N-ATPases, since they seem to form a distinct group that is further apart from usual F-ATPases than A-ATPases are from V-ATPases.
Human delta subunit of ATP synthase is coded by <a href="/facts/Gene/e1swwPY6">gene</a> <a href="/facts/ATP5O/1xSGe5HE">ATP5O</a>.

ATP synthase delta/OSCP subunit open-in-new

ATP synthase delta/OSCP subunit